Identification of Transmission Chains and Clusters Associated with COVID-19 in Tunisia
| Autor: | Chedli Amich, Houcine Jabrane, Mongi Hammami, Latifa Abdelkader, Sondes Darouiche, Fethi Ltaief, Chahida Harizi, A. Sriha, Gharbi D, Hamida Ben Salah, Nejib Charaa, Nabil Ouerfeli, Leila Bouabid, Nawel Elmili, Nissaf Ben Alaya, Souha Bougatef, Sonia Khalfallah, Moncef Mhamdi, H Letaief, Mohamed Kouni Chahed, Rim Moussa, Manel Ben Fredj, Hasna Termiz, Salah Zoghlami, Mohamed Makhlouf, Radhia Dabghi, Habib Tounekti, Khouloud Talmoudi, Zid Anez, Mouna Safer, Aicha Hechaichi, Selma Mchirgui, Sonia Dhaouadi |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Tunisia Coronavirus disease 2019 (COVID-19) Virus transmission Secondary infection 030231 tropical medicine Infectious and parasitic diseases RC109-216 Coronavirus infections / transmission Biology Virus law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Cluster analysis Contact tracing law Nasopharynx Humans 030212 general & internal medicine Aged Aged 80 and over Public health Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 COVID-19 Middle Aged Virology First generation Infectious Diseases Transmission (mechanics) RNA Viral Female Early phase Research Article |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021) |
| Popis: | Background The aim of this study was to characterize the transmission chains and clusters of COVID-19 infection in Tunisia. Methods All cases were confirmed by Reverse Transcriptase Polymerase Chain Reaction of a nasopharyngeal specimen. Contact tracing is undertaken for all confirmed cases in order to identify close contacts that will be systematically screened and quarantined. Transmission chains were identified based on field investigation, contact tracing, results of screening tests and by assessing all probable mode of transmission and interactions. Results As of May 18, 2020, 656 cases out of a total of 1043 confirmed cases of Coronavirus disease 2019 belong to 127 transmission chains identified during the epidemic (mean age 42.36 years, Standard deviation 19.56 and sex ratio 0.86). The virus transmission is the most concentrated in the governorate of Tunis (31.5%), Ariana (10.2%) and Ben Arous (10.2%). Virus transmission occurred 50 times (9.72% of secondary transmission events) between two different governorates. A maximum of seven generations of secondary infection was identified, whereas 62% of these secondary infections belong the first generation. A total of 11 “super spreader” cases were identified in this investigation. Four large clusters have been identified. The evolution of secondary cases highlighted two peaks: one in 2nd April and a second in 16 th April whereas imported cases caused local transmission of virus during the early phase of the epidemic. Conclusion Correct contact tracing and early active case finding is useful to identify transmission chains and source of infection in order to contain the widespread transmission in the community. |
| Databáze: | OpenAIRE |
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