Low vitamin D levels are independent predictors of 1-year worsening in physical function in people with chronic spinal cord injury: a longitudinal study
| Autor: | Alessio Martorella, Giorgio Felzani, Arcangelo Barbonetti, Settimio D'Andrea, Sandro Francavilla, Felice Francavilla |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Longitudinal study medicine.medical_specialty Activities of daily living medicine.medical_treatment 030209 endocrinology & metabolism Comorbidity Neurology Neurology (clinical) 03 medical and health sciences Leisure Activities 0302 clinical medicine Internal medicine Activities of Daily Living Linear regression medicine Vitamin D and neurology Humans Longitudinal Studies Vitamin D Exercise Spinal cord injury Spinal Cord Injuries Rehabilitation business.industry General Medicine Middle Aged Prognosis Vitamin D Deficiency medicine.disease Treatment Outcome ROC Curve Chronic Disease Disease Progression Population study Female business 030217 neurology & neurosurgery |
| Zdroj: | Spinal Cord. 56:494-501 |
| ISSN: | 1476-5624 1362-4393 |
| DOI: | 10.1038/s41393-017-0058-7 |
| Popis: | STUDY DESIGN Longitudinal cohort study. OBJECTIVE To explore the longitudinal association of baseline vitamin D levels with 1-year change in physical function outcomes in people with chronic spinal cord injury (SCI). SETTING Rehabilitation institute. METHODS Sixty-seven patients (44 men and 23 women) with chronic SCI admitted to a rehabilitation program were included. Functional independence in daily living activities (as evaluated by the Spinal Cord Independence Measure version III, SCIM III) and leisure time physical activity (LTPA) were assessed as measures of physical function at the admission and re-assessed 1-year later. Comorbidity was scored by Charlson comorbidity index (CCI). RESULTS A 1-year worsening in SCIM and LTPA were registered in 44 and 40 patients (66% and 60% of the study population), respectively. They exhibited significantly lower baseline 25(OH)D levels, higher CCI, and shorter distance from the injury. At the multiple linear regression analyses, lower baseline 25(OH)D levels exhibited a significant independent association with higher percentages of 1-year worsening in both SCIM and LTPA. At ROC analysis, baseline 25(OH)D levels |
| Databáze: | OpenAIRE |
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