Visfatin Levels May be an Early Marker of Atherosclerosis in Patients with Acromegaly
| Autor: | Sibel Ocak Serin, Hamide Piskinpasa, Sema Ciftci Dogansen, Osman Pirhan, Asuman Gedikbasi, Yildiz Okuturlar, Mine Adas, Aysegul Akdogan Gemici, Sogol Sadri, Meral Mert, Yasemin Sefika Akdeniz, Ayşe Esen |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Cross-sectional study Endocrinology Diabetes and Metabolism Clinical Biochemistry 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Biochemistry Carotid Intima-Media Thickness 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Diabetes mellitus Internal medicine Acromegaly medicine Humans In patient Insulin-Like Growth Factor I Nicotinamide Phosphoribosyltransferase Glycemic Glycated Hemoglobin business.industry Human Growth Hormone Biochemistry (medical) Case-control study General Medicine Middle Aged medicine.disease Atherosclerosis Prognosis Cross-Sectional Studies Intima-media thickness chemistry Case-Control Studies Cytokines Female Glycated hemoglobin business Biomarkers Follow-Up Studies |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 51(10) |
| ISSN: | 1439-4286 |
| Popis: | The purpose of the study was to compare serum visfatin levels between patients with acromegaly and healthy controls and to evaluate the relationships between visfatin levels and epicardial fat thickness (EFT), carotid intima media thickness (cIMT), and ankle brachial index (ABI). We conducted a cross-sectional case-control study of 54 patients with acromegaly (37 females and 17 males) and 34 healthy controls (22 females and 12 males). Serum visfatin was measured by ELISA. Acromegalic and control participants and those with active or controlled acromegaly were compared with respect to their serum visfatin, clinical and metabolic parameters, EFT, cIMT, and ABI. Linear correlation was used to identify associations between these parameters and visfatin in all participants. Serum visfatin and glycated hemoglobin (HbA1c) were higher in the acromegaly group than in the control group (p |
| Databáze: | OpenAIRE |
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