DNA methylation is associated with airflow obstruction in patients living with HIV
| Autor: | Ken M. Kunisaki, J.L. MacIsaac, Ana I. Hernández Cordero, Janice M. Leung, Ma'en Obeidat, Richard M. Novak, Chen Xi Yang, Michael S. Kobor, Julia Yang, Hartwig Klinker, Nila J. Dharan, David T.S. Lin, Lisa M. McEwen, Don D. Sin, Fleur Hudson, Sf Paul Man |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Oncology medicine.medical_specialty Chronic Obstructive Pulmonary Disease HIV Infections COPD ÀÜ mechanisms Pulmonary Disease Chronic Obstructive 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Epigenetics Immunodeficiency 030304 developmental biology 0303 health sciences COPD business.industry Methylation DNA Methylation Middle Aged respiratory system medicine.disease Respiratory Function Tests respiratory tract diseases respiratory measurement Ageing Cohort DNA methylation Female viral infection business immunodeficiency circulatory and respiratory physiology |
| Zdroj: | Thorax |
| ISSN: | 1468-3296 0040-6376 |
| DOI: | 10.1136/thoraxjnl-2020-215866 |
| Popis: | IntroductionPeople living with HIV (PLWH) suffer from age-related comorbidities such as COPD. The processes responsible for reduced lung function in PLWH are largely unknown. We performed an epigenome-wide association study to investigate whether blood DNA methylation is associated with impaired lung function in PLWH.MethodsUsing blood DNA methylation profiles from 161 PLWH, we tested the effect of methylation on FEV1, FEV1/FVC ratio and FEV1 decline over a median of 5 years. We evaluated the global methylation of PLWH with airflow obstruction by testing the differential methylation of transposable elements Alu and LINE-1, a well-described marker of epigenetic ageing.ResultsAirflow obstruction as defined by a FEV1/FVC1/FVC1 and FEV1/FVC, respectively. No positions were associated with FEV1 decline.ConclusionA large number of DMPs were associated with airflow obstruction and lung function in a unique cohort of PLWH. Airflow obstruction in even relatively young PLWH is associated with global hypomethylation, suggesting advanced epigenetic ageing compared with those with normal lung function. The disturbance of the epigenetic regulation of key genes not previously identified in non-HIV COPD cohorts could explain the unique risk of COPD in PLWH. |
| Databáze: | OpenAIRE |
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