In vitro antibacterial effects of topical local anesthetics

Autor:	Altan Aksoy, Osman Caglayan, Ünase Büyükkoçak, J. Sedef Göçmen
Rok vydání:	2008
Předmět:	Staphylococcus aureus medicine.drug_class Streptococcus pyogenes Mupirocin Dermatology Microbial Sensitivity Tests Pharmacology In Vitro Techniques medicine.disease_cause Administration Cutaneous Enterococcus faecalis Prilocaine chemistry.chemical_compound Staphylococcus epidermidis medicine Escherichia coli Humans local anesthetics topical Anesthetics Local Antibacterial agent biology business.industry Local anesthetic Lidocaine Reproducibility of Results biology.organism_classification Anti-Bacterial Agents chemistry Pseudomonas aeruginosa Drug Therapy Combination Antibacterial activity business medicine.drug
Zdroj:	The Journal of dermatological treatment. 19(6)
ISSN:	1471-1753
Popis:	WOS: 000260926400005 PubMed: 18608709 Background: The antibacterial activities of local anesthetics are recognized. Objective: To investigate in vitro the activity of topical local anesthetic ointments at clinical doses. Methods: The activity of two different local anesthetic ointments including lidocaine 5% and lidocaine/prilocaine 2.5% was tested against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Streptococcus pyogenes and Enterococcus faecalis by the disc-diffusion method. Sterile discs containing topical local anesthetic drugs were prepared taking into account the doses of ointments used in clinical practice. The validity of the methodology was confirmed using topical antibacterial mupirocin. The inhibition zones of the discs were measured. Results: Mupirocin inhibited all the bacteria. Both local anesthetic ointments were found to be most effective on E. coli, whereas they had no effects on P. aeruginosa. Lidocaine 5% revealed antibacterial activity against S. aureus, S. epidermidis, E. coli, S. pyogenes and E. faecalis, but lidocaine/prilocaine 2.5% showed no activity on E. faecalis and inhibited S. pyogenes only at double doses. It was also observed that the antibacterial activity was in a dose-dependent manner. Conclusion: In the light of these findings, it might be concluded that topical local anesthetic ointments in routine settings may have a preventive role against some bacteria.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6502e1fa3be284b5a46b82d032b8098 https://pubmed.ncbi.nlm.nih.gov/18608709 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.