Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites
| Autor: | Saharon Rosset, Carlos Bustamante, Ajai Kumar Pathak, Richard Villems, Mait Metspalu, Ene Metspalu, Siiri Rootsi, Doron M. Behar, Toomas Kivisild, G. David Poznik, Alice A. Lin, Hovhannes Sahakyan, Viola Grugni, Peter A. Underhill, Mari Järve, Karl Skorecki, Shay Tzur, Ben Passarelli, Ornella Semino, Natalie M. Myres |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Lineage (genetic) endocrine system diseases General Physics and Astronomy Biology Y chromosome Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Haplogroup Article 03 medical and health sciences Gene Frequency Phylogenetics Humans Europe Eastern Phylogeny 030304 developmental biology 0303 health sciences Multidisciplinary Chromosomes Human Y Phylogenetic tree 030305 genetics & heredity Haplotype nutritional and metabolic diseases Genetic Variation General Chemistry Sequence Analysis DNA Eastern european Haplotypes Evolutionary biology Jews Founder effect |
| Zdroj: | Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Previous Y-chromosome studies have demonstrated that Ashkenazi Levites, members of a paternally inherited Jewish priestly caste, display a distinctive founder event within R1a, the most prevalent Y-chromosome haplogroup in Eastern Europe. Here we report the analysis of 16 whole R1 sequences and show that a set of 19 unique nucleotide substitutions defines the Ashkenazi R1a lineage. While our survey of one of these, M582, in 2,834 R1a samples reveals its absence in 922 Eastern Europeans, we show it is present in all sampled R1a Ashkenazi Levites, as well as in 33.8% of other R1a Ashkenazi Jewish males and 5.9% of 303 R1a Near Eastern males, where it shows considerably higher diversity. Moreover, the M582 lineage also occurs at low frequencies in non-Ashkenazi Jewish populations. In contrast to the previously suggested Eastern European origin for Ashkenazi Levites, the current data are indicative of a geographic source of the Levite founder lineage in the Near East and its likely presence among pre-Diaspora Hebrews. Population genetics studies continue to debate whether Ashkenazi Levites originated in Europe or the Near East. Here, Rootsi et al. use whole Y-chromosome DNA sequences to unravel the phylogenetic origin of the Ashkenazi Levite and suggest an origin for the Levite founder lineage in the Near East. |
| Databáze: | OpenAIRE |
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