Therapeutic impact of 18FDG-PET/CT in the management of iodine-negative recurrence of differentiated thyroid carcinoma
| Autor: | Arnaud Murat, C. Curtet, Bruno Carnaille, Thomas Guillan, Catherine Ansquer, Caroline Rousseau, Eric Mirallié, Isabelle Resche, B. Bridji, Françoise Kraeber-Bodéré, Bernard Charbonnel, Caroline Bodet-Milin |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Adolescent medicine.medical_treatment Thyroglobulin Thyroid carcinoma Fluorodeoxyglucose F18 Adenocarcinoma Follicular medicine Adenoma Oxyphilic Humans Prospective Studies Thyroid Neoplasms Prospective cohort study Thyroid cancer Aged Aged 80 and over medicine.diagnostic_test business.industry Patient Selection Thyroid Thyroidectomy Cell Differentiation Middle Aged medicine.disease medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography Mediastinal lymph node Female Surgery Neoplasm Recurrence Local Radiopharmaceuticals Tomography X-Ray Computed Nuclear medicine business |
| Zdroj: | Surgery. 142:952-958 |
| ISSN: | 0039-6060 |
| DOI: | 10.1016/j.surg.2007.09.015 |
| Popis: | Background 18-F-fluoro-2-deoxyglucose positron emission tomography (18FDG-PET) is useful in the detection of iodine-negative differentiated thyroid carcinoma (DTC). The aim of this prospective study was to assess therapeutic impact of 18FDG-PET imaging using a PET/computed tomography (CT) system in patients with iodine-negative recurrence of DTC. Methods From 2002 to 2006, patients with recurrence of DTC diagnosed by elevated thyroglobulin level and negative 131-I whole-body scan were included. Results Forty-five patients (31 women, 14 men), with a mean age of 55 years, with 36 papillary, 5 follicular, and 4 Hurthle carcinomas, were studied. All patients had previously undergone total thyroidectomy and postoperative thyroid remnant ablation with 131-I. The findings of 18FDG-PET/CT were positive in 31 patients (68.8%) and negative in 14 (32.2%). Results were true positive in 24 of 31 patients. The sensitivity, positive predictive value, and accuracy of 18FDG-PET/CT were 63%, 77%, and 53%, respectively. Twenty patients were operated on, 19 had neck surgery with mediastinal lymph node dissection (1 case) and lung resection (1 case), and 1 underwent lung resection. Seven patients had a stimulated thyroglobulin level Conclusion 18FDG-PET/CT is able to select patients who can benefit from surgery. Normalization of thyroglobulin is observed in one third of operated patients. |
| Databáze: | OpenAIRE |
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