Network Systems Biology for Drug Discovery
| Autor: | D K Arrell, Andre Terzic |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
Models Statistical Drug discovery Receptors Drug Systems Biology Systems biology Drug Evaluation Preclinical Gene regulatory network Computational Biology Proteins Computational biology Biology Bioinformatics Drug Delivery Systems ComputingMethodologies_PATTERNRECOGNITION Drug Discovery Gene Regulatory Networks Pharmacology (medical) Identification (biology) Organism Network analysis |
| Zdroj: | Clinical Pharmacology & Therapeutics. 88:120-125 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.2010.91 |
| Popis: | Systems biology provides a platform for integrating multiple components and interactions underlying cell, organ, and organism processes in health and disease. Beyond traditional approaches focused on individual molecules or pathways, bioinformatic network analysis of high-throughput data sets offers an opportunity for integration of biological complexity and multilevel connectivity. Emerging applications in rational drug discovery range from targeting and modeling disease-corrupted networks to screening chemical or ligand libraries to identification/validation of drug-target interactions for improved efficacy and safety. |
| Databáze: | OpenAIRE |
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