Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation
| Autor: | Mohammed Arshaduddin, Hamoud Al Shahrani, Nasser Al Masri, Ahmed Al Faraidi, Abdulrahman Al Asmari, Ibrahim Elfaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Health Toxicology and Mutagenesis Inflammation Pharmacology Toxicology medicine.disease_cause Ulcer index Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:RA1190-1270 medicine Pylorus ligation lcsh:Toxicology. Poisons Ethanol Gastric ulcers Chemistry Vanillin digestive oral and skin physiology Malondialdehyde Pylorus Mucus digestive system diseases 030104 developmental biology medicine.anatomical_structure Biochemistry Oxidative stress 030220 oncology & carcinogenesis medicine.symptom |
| Zdroj: | Toxicology Reports, Vol 3, Iss, Pp 105-113 (2016) Scipedia Open Access Scipedia SL Toxicology Reports |
| ISSN: | 2214-7500 |
| Popis: | Vanillin is commonly used as an additive in food, medicine and cosmetics, but its effect has not yet been studied in gastric injury. Therefore the effect of vanillin was studied in experimental gastric ulcer. Gastric secretion and acidity were studied in pylorus ligated rats. Ulcer index, levels of gastric mucus, malondialdehyde (MDA), myeloperoxidase activity (MPO), expression of nuclear factor kappa B (NF-κB) p65, and histopathological changes were determined in ethanol induced gastric ulcer. Pre treatment with vanillin significantly reduced gastric secretion (P |
| Databáze: | OpenAIRE |
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