Human glutaminyl cyclase: Structure, function, inhibitors and involvement in Alzheimer’s disease
| Autor: | Kam Y.J. Zhang, Dileep K. Vijayan |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Gene isoform Chemokine Protein Conformation Amyloid beta Disease CCL2 03 medical and health sciences symbols.namesake 0302 clinical medicine Alzheimer Disease Animals Humans Neuroinflammation Pharmacology chemistry.chemical_classification biology Chemistry Golgi apparatus Aminoacyltransferases Neuroprotective Agents 030104 developmental biology Enzyme Biochemistry 030220 oncology & carcinogenesis symbols biology.protein |
| Zdroj: | Pharmacological Research. 147:104342 |
| ISSN: | 1043-6618 |
| Popis: | Human glutaminyl cyclase (hQC) is an important enzyme for post-translational modification by converting the N-terminal glutaminyl and glutamyl into pyroglutamate (pGlu) through cyclization. The two isoforms of hQC, secretory glutaminyl cyclase (sQC) and golgi resident glutaminyl cyclase (gQC), are involved in various pathological conditions especially in Alzheimer's disease (AD). The sQC is known to mediate the formation of pyroglutamate containing amyloid beta (pGlu-Aβ) peptides while gQC mediates the maturation of C-C motif chemokine ligand 2 (CCL2). Therefore, hQC (both sQC and gQC) inhibition is considered to be an attractive strategy to prevent the formation of pGlu-Aβ and to reduce neuroinflammation and hence provides a new opportunity for the treatment of AD. In this review, we summarize our current understanding on the structure, function and inhibitors of hQC and its involvement in Alzheimer's disease. |
| Databáze: | OpenAIRE |
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