Sweet taste loss in myasthenia gravis: more than a coincidence?
| Autor: | Joelle N Chabwine, Anastasia Zekeridou, Muriel Tschirren, Thierry Kuntzer, Basile Nicolas Landis |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Taste
Thymoma Sweet taste Dysgeusia stomatognathic system Taste receptor medicine Genetics(clinical) Pharmacology (medical) Letter to the Editor Myasthenia gravis Genetics (clinical) Autoimmune disease Medicine(all) business.industry General Medicine medicine.disease ddc:616.8 Taste disorder Immunology medicine.symptom business |
| Zdroj: | Orphanet Journal of Rare Diseases Orphanet Journal of Rare Diseases, vol. 9, no. 1, pp. 50-53 Orphanet Journal of Rare Diseases, Vol. 9, No 1 (2014) P. 50 |
| ISSN: | 1750-1172 |
| Popis: | Sweet dysgeusia, a rare taste disorder, may be encountered in severe anti-acetylcholine receptor antibody (AChRAb)-myasthenia gravis (MG). A 42 year-old man reported progressive loss of sweet taste evolving for almost 10 weeks, revealing an AChRAb-positive MG with thymoma. Improvement of sweet perception paralleled reduction of the MG composite score during the 15 months follow up period, with immunosuppressive and surgical treatments. We suggest that sweet dysgeusia is a non-motor manifestation of MG that may result from a thymoma-dependent autoimmune mechanism targeting gustducin-positive G-protein-coupled taste receptor cells, in line with recent data from MRL/MpJ-Fas lpr/ (MRL/lpr) transgenic mice with autoimmune disease. |
| Databáze: | OpenAIRE |
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