Time course of renal sodium transport in the pregnant rat
| Autor: | Shyama M. E. Masilamani, Steven D. Beck, Crystal A. West |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Epithelial sodium channel
medicine.medical_specialty Physiology Sodium Short Communication chemistry.chemical_element Specialties of internal medicine Nephron chemistry.chemical_compound Furosemide Internal medicine Benzamil medicine QP1-981 Kidney Pregnancy biology business.industry General Medicine Pendrin medicine.disease medicine.anatomical_structure Endocrinology chemistry RC581-951 biology.protein business Thiazide medicine.drug |
| Zdroj: | Current Research in Physiology Current Research in Physiology, Vol 4, Iss, Pp 229-234 (2021) |
| ISSN: | 2665-9441 |
| Popis: | Progressive sodium retention and cumulative plasma volume expansion occur to support the developing fetus during pregnancy. Sodium retention is regulated by individual tubular transporters and channels. An increase or decrease in any single transporter could cause a change in sodium balance. Understanding the time-course for changes in each sodium transporter during pregnancy will enable us to understand progressive sodium retention seen in pregnancy. Here, we examined the activity of the major apical sodium transporters found in the nephron using natriuretic response tests in virgin, early pregnant, mid-pregnant, and late pregnant rats. We also measured renal and serum aldosterone levels. We found that furosemide sensitive sodium transport (NKCC2) is only increased during late pregnancy, thiazide sensitive sodium transport (NDCBE/pendrin) is increased in all stages of pregnancy, and that benzamil sensitive sodium transport (ENaC) is increased beginning in mid-pregnancy. We also found that serum aldosterone levels progressively increased throughout gestation and kidney tissue aldosterone levels increased only during late pregnancy. Here we have shown progressive turning on of specific sodium transport mechanisms to help support progressive sodium retention through the course of gestation. These mechanisms contribute to the renal sodium retention and plasma volume expansion required for an optimal pregnancy. Highlights • NKCC2 activity is only increased during late pregnancy. • Thiazide sensitive sodium transport, likely mediated by NDCBE/pendrin, is increased in all stages of pregnancy. • ENaC activity is increased beginning in mid-pregnancy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|