Brief Report: Prolonged Viral Suppression Over a 12-Year Follow-up of HIV-Infected Patients: The Persistent Impact of Adherence at 4 Months After Initiation of Combined Antiretroviral Therapy in the ANRS CO8 APROCO-COPILOTE Cohort
| Autor: | Janine Pierret, Camelia Protopopescu, François Raffi, Bruno Spire, O. Picard, Lucile Hardel, Lionel Piroth, Corinne Jadand, Maria Patrizia Carrieri, Catherine Leport |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Time Factors Sustained Virologic Response HIV Infections Logistic regression Medication Adherence 03 medical and health sciences 0302 clinical medicine Antiretroviral Therapy Highly Active Internal medicine medicine Humans Hiv infected patients Pharmacology (medical) Prospective Studies 030212 general & internal medicine Viral suppression Anthracenes business.industry Odds ratio 030112 virology Antiretroviral therapy Confidence interval Regimen Infectious Diseases Anti-Retroviral Agents Cohort Female business Follow-Up Studies |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 74:293-297 |
| ISSN: | 1525-4135 |
| DOI: | 10.1097/qai.0000000000001249 |
| Popis: | The effect of early adherence on long-term viral suppression was assessed among 1281 patients with HIV starting a protease inhibitor-containing regimen in 1997-1999, followed up to 12 years. Association between 4-month adherence (3-level score) and prolonged viral suppression was evaluated using a multivariate mixed logistic model in 891 eligible patients. High 4-months adherence [odds ratio (95% confidence interval): 3.72 (1.98 to 6.98)] was associated with long-term prolonged viral suppression, irrespective of maintenance adherence. This unexpected long-term virological impact of early adherence reinforces the message that, when starting antiretrovirals, all means should be mobilized to ensure optimum early adherence to achieve prolonged antiretroviral success. |
| Databáze: | OpenAIRE |
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