Reversible encephalopathy associated with tacrolimus in pediatric renal transplants
| Autor: | A. M. G. O’Gorman, M. Pinsk, P. Parvex, Yves Patenaude, Lorraine Bell, Indra R. Gupta |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Adolescent medicine.medical_treatment Encephalopathy Gastroenterology Tacrolimus Prednisone Internal medicine Humans Medicine Child Brain Diseases Chemotherapy business.industry medicine.disease Kidney Transplantation Magnetic Resonance Imaging Surgery Calcineurin Transplantation surgical procedures operative Pediatrics Perinatology and Child Health Kidney Failure Chronic Female business Complication Immunosuppressive Agents medicine.drug |
| Zdroj: | Pediatric Nephrology. 16:537-542 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s004670100602 |
| Popis: | Neurological complications post transplant have been described with the use of calcineurin inhibitors. Although tacrolimus may be a better immunosuppressant than cyclosporine, its neurological side effects may be worse. Two children, living-related kidney transplant recipients, were treated with antibody induction, mycophenolate mofetil, prednisone, and tacrolimus. Soon after transplant, they each developed an encephalopathy, which when visualized by magnetic resonance imaging showed that it affected both white and grey matter of the brain. Although the encephalopathy was associated with the use of tacrolimus, there was a complete neurological recovery without cessation of the drug. |
| Databáze: | OpenAIRE |
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