Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
| Autor: | Yuhong Jing, Eiko Sakurai, Kazuhiko Yanai, Nobuyuki Okamura, Atsuo Kuramasu, Motohisa Kato, Kenya Kaneko, Satoshi Fujii, Ajing Xu, Hiroshi Kato, Hongmei Dai |
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| Rok vydání: | 2007 |
| Předmět: |
Long-Term Potentiation
Hippocampus Neuropsychological Tests Amygdala Mice Conditioning Psychological medicine Animals Receptors Histamine H2 Receptors Histamine H1 Fear conditioning Maze Learning Prefrontal cortex Mice Knockout Analysis of Variance General Neuroscience Long-term potentiation Fear General Medicine Barnes maze medicine.anatomical_structure nervous system Synaptic plasticity Memory consolidation Cognition Disorders Psychology Neuroscience |
| Zdroj: | Neuroscience Research. 57:306-313 |
| ISSN: | 0168-0102 |
| DOI: | 10.1016/j.neures.2006.10.020 |
| Popis: | Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarify the role of these receptors in learning and memory processes. Learning and memory were evaluated by several behavioral tasks including object recognition, Barnes maze and fear conditioning. These behavioral tasks are highly dependent on the function of prefrontal cortex, hippocampus or amygdala. Object recognition and Barnes maze performance were significantly impaired in both H1 receptor gene knockout (H1KO) and H2 receptor gene knockout (H2KO) mice when compared to the respective wild-type (WT) mice. Conversely, both H1KO and H2KO mice showed better auditory and contextual freezing acquisition than their respective WT mice. Furthermore, we also examined long-term potentiation (LTP) in the CA1 area of hippocampus in H1KO and H2KO mice and their respective WT mice. LTP in the CA1 area of hippocampus was significantly reduced in both H1KO and H2KO mice when compared with their respective WT mice. In conclusion, our results demonstrate that both H1 and H2 receptors are involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact. |
| Databáze: | OpenAIRE |
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