Micronutrients and T-cell subsets: a comparison between HIV-infected and uninfected, severely malnourished Rwandan children
| Autor: | J. B. S. Coulter, C. Baribwira, F. Ndagije |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Lymphocyte Population HIV Infections Gastroenterology Selenium T-Lymphocyte Subsets Internal medicine Immunopathology medicine Immune Tolerance Humans Micronutrients Sida education education.field_of_study biology Anthropometry business.industry Malnutrition Infant Micronutrient biology.organism_classification medicine.disease CD4 Lymphocyte Count Zinc medicine.anatomical_structure Cross-Sectional Studies El Niño Child Preschool Pediatrics Perinatology and Child Health Female business Copper |
| Zdroj: | Annals of tropical paediatrics. 27(4) |
| ISSN: | 0272-4936 |
| Popis: | To determine the levels of CD4+ cells and micronutrients in HIV-infected and uninfected severely malnourished children.Cross-sectional study in two centres.Children admitted to the malnutrition units in Kigali and Butare, Rwanda.A total of 112 children aged 2 months to 5 years presenting with severe malnutrition (weight for height Z- score -3 SD +/- oedema). Fifty-two (46.4%) were HIV-infected.CD4+ counts, selenium, zinc and copper levels were measured. The percentage of CD4 cells was calculated as a proportion of total lymphocyte count.The mean age of the 52 HIV-infected children (18 months) was lower than of the 60 uninfected children (26 months) (p=0.01). Six (11.5%) of the HIV-infected had oedematous malnutrition compared with 50% of the uninfected group. The mean (SD) CD4+ count was 1054 (780) in the HIV-infected and 1579 (721) in the uninfected group (p=0.001). The CD4+ count was also significantly lower in the HIV-infected group than in the uninfected group for the ages12 mths (p=0.09), 12-24 mths (p=0.045) and36 mths (p=0.001). In HIV-infected children, 17% had severe immunosuppression (15% CD4+ cells), 33% moderate (15-24%) and 50% had none (25%) compared with 9%, 12% and 80% in the HIV-uninfected group, respectively (p0.001). Approximately one-third in both groups had low levels of selenium and zinc and 77% had raised levels of copper. In multivariate analysis there was significant correlation between selenium and CD4+ (r=0.36, p0.001) in HIV-infected children and no correlation of zinc and copper to CD4+ %. In HIV uninfected children, CD4+ % was related to selenium (r=0.282, p=0.03) and to zinc (r=0.264, p=0.047) but not to copper.In severely malnourished children with HIV infection, low CD4+ levels are associated mainly with HIV infection. There was no significant difference in levels of selenium, zinc and copper between HIV-infected and uninfected children. |
| Databáze: | OpenAIRE |
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