GLIPR1 inhibits the proliferation and induces the differentiation of cancer-initiating cells by regulating miR-16 in osteosarcoma
| Autor: | Binna Bi, Lianhai Zhang, Kaituo Gao, Jian Dong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Cancer Research Cellular differentiation Blotting Western Bone Neoplasms Nerve Tissue Proteins Biology Real-Time Polymerase Chain Reaction 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation microRNA medicine Humans Neoplasm Invasiveness neoplasms Cell Proliferation Osteosarcoma Oncogene Membrane Proteins Cancer Cell Differentiation General Medicine Cell cycle medicine.disease Molecular medicine Neoplasm Proteins Cell biology Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Oncology Gene Knockdown Techniques 030220 oncology & carcinogenesis Neoplastic Stem Cells Cancer research |
| Zdroj: | Oncology Reports. 36:1585-1591 |
| ISSN: | 1791-2431 1021-335X |
| Popis: | Osteosarcoma is a common, highly malignant and metastatic bone cancer. Elucidation of the molecular mechanisms of osteosarcoma may further help us to understand the pathogenesis of the disease, and offer novel targets for effective therapies. Human glioma pathogenesis-related protein 1 (GLIPR1) has been found to be downregulated in human cancers. However, its roles have not been reported in osteosarcoma. In the present study, we demonstrated that GLIPR1 protein was downregulated in osteosarcoma. Its overexpression inhibited the proliferation, migration and invasion and induced the differentiation of cancer-initiating cells (CICs) in osteosarcoma. Moreover, GLIPR1 overexpression upregulated miR-16 in osteosarcoma cells. The upregulation suppressed proliferation, migration and invasion as well as induced differentiation of CICs in osteosarcoma. Thus, we conclude that GLIPR1 inhibited the proliferation, migration and invasion and induced the differentiation of CICs by regulating miR-16 in osteosarcoma. The present study provides direct evidence that GLIPR1 is a bona fide tumor suppressor and identified GLIPR1 and miR-16 as key components for regulating the proliferation, migration, invasion and CICs in osteosarcoma. |
| Databáze: | OpenAIRE |
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