AN ARTHOROPATHIC FROM OF OSTEOGENESIS IMPERFECTA
| Autor: | Seppo Similä, Kauko Kouvalainen, M. Remes, E. Sipola, R. Penttinen |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
musculoskeletal diseases
Pathology medicine.medical_specialty Adolescent Long bone Osteoporosis Dentistry medicine Humans Hydroxyprolinuria business.industry General Medicine Osteogenesis Imperfecta medicine.disease Arthritis Juvenile Collagen biosynthesis medicine.anatomical_structure Osteogenesis imperfecta Rheumatoid arthritis Pediatrics Perinatology and Child Health Female Collagen Joint Diseases business Juvenile rheumatoid arthritis Type I collagen |
| Zdroj: | Acta Paediatrica. 69:263-267 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1980.tb07074.x |
| Popis: | Penttinen, R., Sipola, E., Kouvalainen, K., Simila, S. and Remes, M. (Department of Medical Chemistry, University of Turku, and Department of Paediatrics, University of Oulu, Finland). Arthropathic osteogenesis imperfecta. Acta Paediatr Scand, 69:263, 1980.—A 14-year-old girl gradually developed severe osteoporosis and destructive generalized joint disease, resulting in joint stiffness and anchyloses. She also had moderate hydroxyprolinemia and hydroxyprolinuria. Rheumatoid arthritis was highly unlikely. Anamnestic data revealed two long bone fractures. Collagen biosynthesis was studied in fibroblasts cultured from the patient's skin. Chromatograms of 3H-labelled culture media proteins on ion exchange celluloses revealed an increased ratio of type III collagen to type I collagen when compared with the chromatograms of age-matched control fibroblasts. This finding is typical of certain cell strains in osteogenesis imperfecta. The patient might thus express a new variety of osteogenesis imperfecta with chronic arthropathy. |
| Databáze: | OpenAIRE |
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