Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy
| Autor: | Rashida Ahmed, Farrukh Zia Tareen, Javaid A Khan, Yasmin Rahim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Immunofixation
Male Pathology medicine.medical_specialty Lung Neoplasms Paraproteinemias Aftercare malignant and benign haematology Malignancy 03 medical and health sciences 0302 clinical medicine Rare Diseases Rare Disease Biopsy medicine Humans Lung Neoplasms Plasma Cell Multiple myeloma medicine.diagnostic_test biology business.industry General Medicine Chemoradiotherapy Middle Aged medicine.disease lung cancer (oncology) medicine.anatomical_structure Treatment Outcome Immunoglobulin G biology.protein Plasmacytoma 030211 gastroenterology & hepatology Bone marrow Chest radiograph business Multiple Myeloma 030217 neurology & neurosurgery |
| Zdroj: | BMJ Case Reports |
| ISSN: | 1757-790X |
| Popis: | Extramedullaryplasmacytoma (EMP) represents a peculiar and typically progressive malignancy that can originate outside the bone marrow. Primary pulmonary plasmacytoma (PPP) is a rare subset of EMP, confined to the lung. A 55-year-old man, diabetic, non-smoker presented to our clinic with a right chest wall swelling. A routine chest radiograph showed a well-circumscribed opacity in the right upper lung zone. A CT of the chest revealed a large right upper lobe mass with extensive local infiltration. Biopsy and immunohistochemical evaluation led to a diagnosis of PPP. Screening for multiple myeloma was negative. Serum immunofixation showed an IgG lambda monoclonal gammopathy, found in a minority of PPP patients. In view of disease extent, treatment with chemotherapy and radiotherapy was initiated. The patient is currently in out patient follow-up and has shown a favourable response to the treatment with a considerable decrease in serum IgG levels. |
| Databáze: | OpenAIRE |
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