Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial
| Autor: | Thiago Rangel, Laís Fernanda Ferreira Ferraz, Ingrid Fernandes Mathias-Santamaria, Dimitris N. Tatakis, Renato Corrêa Viana Casarin, Amanda Rossato, Manuela Maria Viana Miguel, Mauro Pedrine Santamaria |
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| Přispěvatelé: | Universidade Estadual Paulista (UNESP), University of Maryland School of Dentistry, Piracicaba Dental School, The Ohio State University (OSU), University of Kentucky |
| Rok vydání: | 2021 |
| Předmět: |
Dentistry
wound healing patient outcome assessment law.invention Free gingival graft Randomized controlled trial Dental Enamel Proteins law enamel matrix proteins Enamel matrix derivative Medicine Humans Gingival Recession Dental Enamel Gingival recession palate Wound Healing Mucous Membrane Enamel paint business.industry Palate gingival recession Wound area visual_art visual_art.visual_art_medium Periodontics Wound fluid medicine.symptom business Wound healing |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1600-0765 |
| Popis: | Made available in DSpace on 2022-05-01T09:30:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Background: This study was conducted to evaluate the clinical, immunologic, and patient-centered outcomes of enamel matrix protein derivative (EMD) on excisional wounds in palatal mucosa. Materials: Forty-four patients in need of ridge preservation were randomly allocated into two groups: control group (n = 22): open palatal wound after free gingival graft (FGG) harvest and EMD group (n = 22): open palatal wound after FGG harvest that received 0.3 ml of EMD. Clinical and patient-centered parameters were analyzed for 3 months post-treatment. Wound fluid levels of inflammatory markers were assessed 3 and 7 days postoperatively. Results: No significant inter-group difference was observed in remaining wound area and re-epithelialization. EMD and control groups achieved wound closure and re-epithelialization 30 days postoperatively (p .05). EMD appeared to selectively modulate wound fluid levels of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, matrix metallopeptidase 9, and tissue inhibitor of metalloproteinases-2. Conclusion: Within the limits of the present study, it can be concluded that EMD application to excisional palatal wounds using the investigated protocol does not provide clinical healing benefits, despite an apparent modulation of selected inflammatory markers. São Paulo State University (UNESP) Division of Periodontics Institute of Science and Technology Division of Operative Dentistry Department of General Dentistry University of Maryland School of Dentistry Department of Prosthodontics and Periodontics Division of Periodontics Piracicaba Dental School College of Dentistry Division of Periodontology The Ohio State University (OSU) College of Dentistry - Lexington University of Kentucky São Paulo State University (UNESP) Division of Periodontics Institute of Science and Technology |
| Databáze: | OpenAIRE |
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