Restrictive filling pattern is associated with increased humoral activation and impaired exercise capacity in dilated cardiomyopathy
| Autor: | Frangiskos I. Parthenakis, Panos E. Vardas, Alexander P. Patrianakos, Dragana Nikitovic, Panagiotis G. Tzerakis, Evangelos A. Papadimitriou, George F. Diakakis |
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| Rok vydání: | 2003 |
| Předmět: |
Cardiomyopathy
Dilated Male medicine.medical_specialty medicine.drug_class Cardiomyopathy Diastole Enzyme-Linked Immunosorbent Assay Sensitivity and Specificity Proinflammatory cytokine Internal medicine Natriuretic Peptide Brain Natriuretic peptide Medicine Humans Receptors Tumor Necrosis Factor Type II Interleukin 6 Aged Ejection fraction Exercise Tolerance biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Dilated cardiomyopathy Middle Aged medicine.disease ROC Curve Receptors Tumor Necrosis Factor Type I Heart failure biology.protein Cardiology Exercise Test Female Cardiology and Cardiovascular Medicine business Interleukin-1 |
| Zdroj: | European journal of heart failure. 6(6) |
| ISSN: | 1388-9842 |
| Popis: | Objectives: Although heart failure (HF) is characterized by increased proinflammatory cytokines, natriuretic peptide levels and impaired exercise capacity, the effect of concomitant diastolic dysfunction on those parameters has not been adequately studied. Methods: We analyzed circulating levels of IL-1, IL-6, TNF-α and its soluble receptors, sTNFRI and sTNFRII, Nt-ANP and Nt-BNP natriuretic peptides in 81 patients, aged 56±12 years, with non-ischemic dilated cardiomyopathy (NIDC), LVEF 29.7±7.75% and functional NYHA class II-III. An echocardiographic study and cardiopulmonary exercise test (CPE) were performed in all patients. Results: Patients were divided into restrictive (24 patients, group I) and non-restrictive (57 patients, group II) groups, according to their transmitral-filling pattern. No differences in LV dimensions or LVEF were found between the two groups. Group I showed increased levels of IL-6 (P=0.006), TNF-α (P=0.05), sTNFRII (P=0.02), Nt-ANP (P |
| Databáze: | OpenAIRE |
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