Anti-IL-5 monoclonal antibody inhibits allergic late phase bronchial eosinophilia in guinea pigs: a therapeutic approach
| Autor: | K. Nolan, Naresh Chand, J. E. Harrison, S. M. Rooney, William Diamantis, R. D. Sofia, J. Pillar, R. G. Jakubicki |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.drug_class Guinea Pigs medicine.disease_cause Monoclonal antibody Guinea pig Eosinophilia medicine Animals Pharmacology biology medicine.diagnostic_test business.industry Antibodies Monoclonal Aeroallergen Eosinophil medicine.disease Asthma Bronchoalveolar lavage medicine.anatomical_structure Immunology biology.protein Interleukin-5 medicine.symptom Antibody business Infiltration (medical) |
| Zdroj: | European Journal of Pharmacology. 211:121-123 |
| ISSN: | 0014-2999 |
| Popis: | In this study the effect of purified rat anti-mouse IL-5 monoclonal antibody on aeroallergen-induced infiltration of eosinophils in the bronchoalveolar lavage fluid of guinea pigs was studied. The i.p. injection of anti-IL-5 antibody 4 h after aeroallergen challenge inhibited eosinophil infiltration in a dose-dependent fashion. The resulting ED 50 was 10 (3.4–32.8) μg/kg. The clinical therapeutic usefulness of anti-IL-5 or anti-IL-5-producing cells in asthma/allergy treatment remains to be an intriguing possibility. |
| Databáze: | OpenAIRE |
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