Novel associations between parental and newborn cord blood metabolic profiles in the Norwegian Mother, Father and Child Cohort Study
| Autor: | Kirsten B. Holven, Anne Lise Brantsæter, Trond M. Michelsen, Martin Prøven Bogsrud, Linn Kristin Lie Øyri, Tore Henriksen, Stine Marie Ulven, Per Magnus, Marit B. Veierød, Hilde Kristin Brekke, Jeanine E. Roeters van Lennep, Kjetil Retterstøl, Jacob J. Christensen |
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| Přispěvatelé: | Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Apolipoprotein B Offspring Mothers Physiology 030204 cardiovascular system & hematology Cohort Studies MoBa the Norwegian Mother Father and Child Cohort Study Fathers 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine SDG 3 - Good Health and Well-being Pregnancy Sex differences Humans Medicine Metabolic profiling 030212 general & internal medicine Child biology Norway business.industry Cholesterol Infant Newborn Cord blood General Medicine Fetal Blood medicine.disease MBRN Medical Birth Registry of Norway chemistry Metabolome biology.protein Female Apolipoprotein A1 lipids (amino acids peptides and proteins) business Research Article Cohort study Lipoprotein |
| Zdroj: | BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021) BMC Medicine BMC Medicine, 19(1):91. BioMed Central Ltd. |
| ISSN: | 1741-7015 |
| Popis: | Background More than one third of Norwegian women and men between 20 and 40 years of age have elevated cholesterol concentration. Parental metabolic health around conception or during pregnancy may affect the offspring’s cardiovascular disease risk. Lipids are important for fetal development, but the determinants of cord blood lipids have scarcely been studied. We therefore aimed to describe the associations between maternal and paternal peri-pregnancy lipid and metabolic profile and newborn cord blood lipid and metabolic profile. Methods This study is based on 710 mother–father–newborn trios from the Norwegian Mother, Father and Child Cohort Study (MoBa) and uses data from the Medical Birth Registry of Norway (MBRN). The sample included in this study consisted of parents with and without self-reported hypercholesterolemia the last 6 months before pregnancy and their partners and newborns. Sixty-four cord blood metabolites detected by nuclear magnetic resonance spectroscopy were analyzed by linear mixed model analyses. The false discovery rate procedure was used to correct for multiple testing. Results Among mothers with hypercholesterolemia, maternal and newborn plasma high-density lipoprotein cholesterol, apolipoprotein A1, linoleic acid, docosahexaenoic acid, alanine, glutamine, isoleucine, leucine, valine, creatinine, and particle concentration of medium high-density lipoprotein were significantly positively associated (0.001 ≤ q ≤ 0.09). Among mothers without hypercholesterolemia, maternal and newborn linoleic acid, valine, tyrosine, citrate, creatinine, high-density lipoprotein size, and particle concentration of small high-density lipoprotein were significantly positively associated (0.02 ≤ q ≤ 0.08). Among fathers with hypercholesterolemia, paternal and newborn ratio of apolipoprotein B to apolipoprotein A1 were significantly positively associated (q = 0.04). Among fathers without hypercholesterolemia, no significant associations were found between paternal and newborn metabolites. Sex differences were found for many cord blood lipids. Conclusions Maternal and paternal metabolites and newborn sex were associated with several cord blood metabolites. This may potentially affect the offspring’s long-term cardiovascular disease risk. |
| Databáze: | OpenAIRE |
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