Urinary excretion of albumin β2-microglobulin and free light chains during lithium treatment
| Autor: | Erling B. Pedersen, S. Darling, Carl Erik Mogensen, K. Sølling, A. Amdisen |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Time Factors Lithium (medication) Urinary system Clinical Biochemistry Beta-Globulins Urine Lithium Immunoglobulin light chain Excretion Internal medicine medicine Albuminuria Humans Proteinuria Chemistry Beta-2 microglobulin Albumin General Medicine Middle Aged Endocrinology Female Immunoglobulin Light Chains medicine.symptom beta 2-Microglobulin medicine.drug |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 38:269-272 |
| ISSN: | 1502-7686 0036-5513 |
| Popis: | Albumin, beta2-microglobulin and free light chains were determined in urine in nine manic-depressive patients before and at intervals during three months of lithium treatment (longitudinal study). The same determinations were carried out in twenty-seven manic-depressive patients who had been treated with lithium for 3 months to 20 years and also in a control group (transversal study). There were no statistically significant changes in urinary excretions of albumin, beta2-microglobulin and free light chains during the longitudinal study. In one patient albumin excretion gradually increased during the study and remained elevated on reexamination 1 year later. No significant differences were found between the lithium treated patients and control subjects in the transversal study in either albumin, beta2-microglobulin or free light chain excretion. It is not clear whether the increased and sustained albumin excretion in one of the patients was due to lithium or was conincidental. The study shows that in most patients lithium treatment does not affect renal protein excretion. |
| Databáze: | OpenAIRE |
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