Tau protein as a diagnostic and prognostic biomarker in amyotrophic lateral sclerosis
| Autor: | Rossella Spataro, Caterina Maria Gambino, Giulia Bivona, Matteo Vidali, Marcello Ciaccio, Rosaria Vincenza Giglio, Vincenzo La Bella, Tommaso Piccoli, Bruna Lo Sasso, Luisa Agnello, Tiziana Colletti |
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| Přispěvatelé: | Agnello, Luisa, Colletti, Tiziana, Lo Sasso, Bruna, Vidali, Matteo, Spataro, Rossella, Gambino, Caterina Maria, Giglio, Rosaria Vincenza, Piccoli, Tommaso, Bivona, Giulia, La Bella, Vincenzo, Ciaccio, Marcello |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Tau protein tau Proteins Gastroenterology 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Internal medicine Humans Medicine 030212 general & internal medicine Amyotrophic lateral sclerosis ALS biomarker CSF Tau biology business.industry Amyotrophic Lateral Sclerosis Area under the curve Retrospective cohort study Prognosis medicine.disease Confidence interval ROC Curve Neurology biology.protein Biomarker (medicine) Neurology (clinical) Age of onset business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neurology. 28:1868-1875 |
| ISSN: | 1468-1331 1351-5101 |
| DOI: | 10.1111/ene.14789 |
| Popis: | BACKGROUND AND PURPOSE To test the hypothesis that total tau (tTau), tau phosphorylated at threonine 181 (pTau) and pTau/tTau ratio in the cerebrospinal fluid (CSF) are diagnostic and prognostic biomarkers of amyotrophic lateral sclerosis (ALS), we performed a retrospective observational study in a large cohort of ALS patients and controls. METHODS We enrolled 196 ALS patients and 91 controls, who included patients with ALS-mimicking diseases and those with non-neurodegenerative diseases. All patients underwent lumbar puncture for CSF analysis at the time of the diagnostic evaluation or to first referral. We measured tTau and pTau levels in the CSF by chemiluminescence enzyme immunoassay. RESULTS Patients with ALS showed significantly higher levels of CSF tTau and a lower pTau/tTau ratio than controls (tTau: 245 vs. 146 pg/ml; p |
| Databáze: | OpenAIRE |
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