Recombinant human C1 esterase inhibitor treatment for hereditary angioedema attacks in children

Autor: Vesna Grivcheva-Panovska, Markus Magerl, Henriette Farkas, Avner Reshef, Stephen Fritz, Dumitru Moldovan, Bruno Giannetti, Aharon Kessel, Vaclava Gutova, Anurag Relan, Shmuel Kivity, Maria Klimaszewska-Rembiasz
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
complement C1 inactivator proteins
Adolescent
complement C1s
Visual analogue scale
Immunology
Phases of clinical research
hereditary angioedema type I and type II
recombinant proteins
03 medical and health sciences
HUMAN C1-ESTERASE INHIBITOR
0302 clinical medicine
Clinical Protocols
Symptom relief
Internal medicine
medicine
Humans
Immunology and Allergy
Drug Dosage Calculations
030212 general & internal medicine
Adverse effect
child
Angioedema
business.industry
angioedema
Body Weight
Angioedemas
Hereditary

Original Articles
medicine.disease
Confidence interval
Treatment Outcome
030228 respiratory system
Child
Preschool

Others
Pediatrics
Perinatology and Child Health

Hereditary angioedema
Administration
Intravenous

Female
Original Article
medicine.symptom
business
Complement C1 Inhibitor Protein
hereditary
Zdroj: Pediatric Allergy and Immunology
ISSN: 1399-3038
0905-6157
DOI: 10.1111/pai.13065
Popis: Background Attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency (C1‐INH‐HAE) usually begin during childhood or adolescence. However, limited data are available regarding indications and modalities of treatment of children. This study evaluated recombinant human C1‐INH (rhC1‐INH) for HAE attacks in children. Methods This open‐label, phase 2 study included children aged 2‐13 years with C1‐INH‐HAE. Eligible HAE attacks were treated intravenously with rhC1‐INH 50 IU/kg body weight (maximum, 4200 IU). The primary end‐point was time to beginning of symptom relief (TOSR; ≥20 mm decrease from baseline in visual analog scale [VAS] score, persisting for two consecutive assessments); secondary end‐point was time to minimal symptoms (TTMS
Databáze: OpenAIRE
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