Clevudine Inhibits Hepatitis Delta Virus Viremia: a Pilot Study of Chronically Infected Woodchucks
| Autor: | Paul J. Cote, Bud C. Tennant, Chung K. Chu, John L. Casey, Illia A. Toshkov, William E. Hornbuckle, John L. Gerin, Brent E. Korba |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Time Factors
animal diseases viruses Pilot Projects Viremia medicine.disease_cause Antiviral Agents Virus Hepatitis B Chronic Antigen medicine Animals Hepatitis B Virus Woodchuck Pharmacology (medical) Pharmacology Hepatitis B virus biology Arabinofuranosyluracil Woodchuck hepatitis virus Hepatitis Antigens virus diseases biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification Virology United States digestive system diseases Kinetics Infectious Diseases Clevudine Marmota Immunology Viral disease Hepatitis Delta Virus medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 49:4396-4399 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | In a small controlled study, clevudine, a potent inhibitor of hepadnaviruses, including hepatitis B virus and woodchuck hepatitis virus, suppressed hepatitis delta virus (HDV) viremia in chronically infected woodchucks. Suppression was correlated with the marked reduction of woodchuck hepatitis virus surface antigen in individual animals, consistent with the concept that repression of surface antigen expression may be a useful antiviral strategy for HDV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|