Transplant genetics and genomics
| Autor: | Joshua Y. C. Yang, Minnie M. Sarwal |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Graft Rejection
0301 basic medicine medicine.medical_treatment Genome-wide association study Genomics Disease 030230 surgery Biology 03 medical and health sciences 0302 clinical medicine Genetics medicine Humans Genetic Predisposition to Disease Genetic Testing Precision Medicine Molecular Biology Genetics (clinical) Genetic association business.industry Genetic Variation Immunosuppression Organ Transplantation Transplantation 030104 developmental biology Identification (biology) Personalized medicine business Genome-Wide Association Study |
| Zdroj: | Nature Reviews Genetics. 18:309-326 |
| ISSN: | 1471-0064 1471-0056 |
| DOI: | 10.1038/nrg.2017.12 |
| Popis: | Ever since the discovery of the major histocompatibility complex, scientific and clinical understanding in the field of transplantation has been advanced through genetic and genomic studies. Candidate-gene approaches and recent genome-wide association studies (GWAS) have enabled a deeper understanding of the complex interplay of the donor-recipient interactions that lead to transplant tolerance or rejection. Genetic analysis in transplantation, when linked to demographic and clinical outcomes, has the potential to drive personalized medicine by enabling individualized risk stratification and immunosuppression through the identification of variants associated with immune-mediated complications, post-transplant disease or alterations in drug-metabolizing genes. |
| Databáze: | OpenAIRE |
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