Central injection of astressin inhibits carbon tetrachloride-induced acute liver injury in rats
| Autor: | Yukiomi Nakade, Hajime Watanobe, Keisuke Tamori, Masashi Yoneda, Kimihide Nakamura, Toru Kono, Isao Makino, Akira Terano, Shiro Yokohama |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Corticotropin-Releasing Hormone medicine.medical_treatment Liver Cirrhosis Experimental chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Pharmacology Liver injury biology Dose-Response Relationship Drug business.industry Carbon Tetrachloride Poisoning Alanine Transaminase medicine.disease Receptor antagonist Vagotomy Cytoprotection Denervation Peptide Fragments Rats Endocrinology Neuroprotective Agents Mechanism of action Alanine transaminase chemistry Liver Toxicity biology.protein Carbon tetrachloride medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | European journal of pharmacology. 460(2-3) |
| ISSN: | 0014-2999 |
| Popis: | The effect of intracisternal astressin, a specific and potent corticotropin-releasing factor (CRF)(1) and CRF(2) receptor antagonist on carbon tetrachloride (CCl(4))-induced acute liver injury was investigated in rats. Intracisternal astressin inhibited the elevation of serum alanine aminotransferase level induced by CCl(4). Intracisternal astressin also reduced CCl(4)-induced liver histological changes. The protective effect of central astressin on CCl(4)-induced liver damage was abolished by sympathectomy but not by hepatic branch vagotomy. These findings demonstrate that astressin acts in the central nervous system to induce hepatic cytoprotection, possibly through the sympathetic pathways in rats. These results further establish a role of endogenous CRF in the brain in hepatic pathophysiological regulation. |
| Databáze: | OpenAIRE |
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