Intranasal fluticasone propionate is effective for perennial nonallergic rhinitis with or without eosinophilia
| Autor: | D. Robert Webb, Cindy K. Cook, Albert F. Finn, Ronald E. Westlund, Pamela J. Pepsin, Kathleen Rickard, Eli O. Meltzer |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Randomization Rhinitis Allergic Perennial Adolescent medicine.drug_class Immunology Placebo Gastroenterology Fluticasone propionate Nonallergic rhinitis Double-Blind Method Internal medicine Anti-Allergic Agents Eosinophilia medicine Immunology and Allergy Humans Multicenter Studies as Topic Child Administration Intranasal Fluticasone Aged Randomized Controlled Trials as Topic Skin Tests Aged 80 and over rhinorrhea business.industry Middle Aged medicine.disease Androstadienes Anesthesia Corticosteroid Female medicine.symptom business medicine.drug |
| Zdroj: | Annals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology. 88(4) |
| ISSN: | 1081-1206 |
| Popis: | Background Although response to intranasal corticosteroid therapy has been reported in patients with nonallergic rhinitis with eosinophilic syndrome (NARES), efficacy specifically in non-NARES patients has not been fully characterized. Objective To evaluate the efficacy of intranasal fluticasone propionate (FP) in the treatment of patients with perennial nonallergic rhinitis, with and without nasal eosinophilia. Methods Data from 983 patients in three randomized, double-blind, placebo-controlled PNAR trials were integrated. Patients received a total daily dose of FP 200 μg (n = 332), FP 400 μg (n = 325), or placebo (n = 326) for 28 days. Patients were ≥12 years of age with perennial rhinitis and negative skin tests to all allergens relevant to the geographic region. Nasal eosinophils were evaluated using a five-point scale. Patients were classified as non-NARES with a point score of 0 (n = 674; 69%); patients with a point score between 1 and 4 were classified as NARES (n = 309; 31%). Efficacy of FP was evaluated by the mean change in total nasal symptom score (TNSS), a sum of patient ratings of nasal obstruction, postnasal drip, and rhinorrhea. Results Patients with either NARES or non-NARES had similar statistically significant improvement with FP 200 μg or 400 μg compared with placebo; thus, the total group comprising both varieties of rhinitis responded to FP. In the total population, both FP treatment groups showed significantly greater improvement in TNSS compared with placebo during each week of treatment ( P ≤ 0.002), with mean changes in TNSS for day 22 to day 28 ranging from −84 and −85 in the FP 200 μg and FP 400 μg groups, respectively, to −64 in the placebo group. The three study treatment groups had similar proportions of non-NARES (68 to 69%) and NARES (31 to 32%) patients at baseline. In the non-NARES subgroup, mean changes in TNSS for each treatment group were similar to changes seen in the total population. In the NARES subgroup, mean changes in TNSS for the FP 200 μg and placebo groups were similar to changes seen in the total population; mean change in TNSS for the FP 400 μg group was somewhat greater than changes seen in the total population. Conclusions Intranasal FP is an effective treatment for perennial nonallergic rhinitis with or without nasal eosinophilia (NARES or non-NARES). |
| Databáze: | OpenAIRE |
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