Effect of clomiphene cirate on oestrogen secretion by human granulosa cells in culture
| Autor: | G. Vieitez, G. Pontonnier, C. Clamagirand, Isabelle Bussenot, J. Parinaud |
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| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Granulosa Cells Dose-Response Relationship Drug Estradiol Chemistry Rehabilitation Oestrogen secretion Androstenedione Obstetrics and Gynecology Plasma levels Clomiphene Basal (phylogenetics) Dose–response relationship Endocrinology Reproductive Medicine Internal medicine medicine Humans Female Secretion Follicle Stimulating Hormone Menotropins Cells Cultured |
| Zdroj: | Human Reproduction. 5:533-536 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/oxfordjournals.humrep.a137137 |
| Popis: | The effect of clomiphene citrate (CC) and 17 beta-oestradiol (E2) on oestrogen secretion was studied in human preovulatory granulosa cells in culture. CC stimulated E2 secretion at 1 and 10 ng/ml (respectively, +36 +/- 14% and +33 +/- 5%) in basal conditions but had no effect on FSH-stimulated E2 secretion. On the other hand, E2 had no effect at any of the tested concentrations (0.1 ng/ml to 1000 ng/ml) on its own production. Since the plasma level of CC obtained in clinical use ranges from 1 to 10 ng/ml, this finding could explain the higher plasma oestrogen levels obtained with CC as compared to human menopausal gonadotrophin. |
| Databáze: | OpenAIRE |
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