Fast Electrophysiological Mapping of Rat Cortical Motor Representation on a Time Scale of Minutes during Skin Stimulation
Autor: | Atsushi Iriki, Davide Ricci, Akito Kosugi, Miki Taoka, Junichi Ushiba, Stefano Carli, Luciano Fadiga, Elisa Castagnola |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Topographic profile Wistar Socio-culturale Stimulation Biology Somatosensory system 03 medical and health sciences 0302 clinical medicine Forearm LS5_1 Forelimb medicine Animals Rats Wistar Skin Brain Mapping General Neuroscience Motor Cortex motor representation Somatosensory Cortex ECoG skin stimulation Electric Stimulation Skin stimulation Rats cortical stimulation mapping Electrophysiology 030104 developmental biology medicine.anatomical_structure cortical stimulation mapping ECoG motor representation skin stimulation Motor learning Neuroscience 030217 neurology & neurosurgery |
Popis: | The topographic map of motor cortical representation, called the motor map, is not invariant, but can be altered by motor learning, neurological injury, and functional recovery from injury. Although much attention has been paid to short-term changes of the motor map, robust measures have not been established. The existing mapping methods are time-consuming, and the obtained maps are confounded by time preference. The purpose of this study was to examine the dynamics of the motor map on a timescale of minutes during transient somatosensory input by a fast motor mapping technique. We applied 32-channel micro-electrocorticographic electrode arrays to the rat sensorimotor cortex for cortical stimulation, and the topographic profile of motor thresholds in forelimb muscle was identified by fast motor mapping. Sequential motor maps were obtained every few minutes before, during, and just after skin stimulation to the dorsal forearm using a wool buff. During skin stimulation, the motor map expanded and the center of gravity of the map was shifted caudally. The expansion of the map persisted for at least a few minutes after the end of skin stimulation. Although the motor threshold of the hotspot was not changed, the area in which it was decreased appeared caudally to the hotspot, which may be in the somatosensory cortex. The present study demonstrated rapid enlargement of the forelimb motor map in the order of a few minutes induced by skin stimulation. This helps to understand the spatial dynamism of motor cortical representation that is modulated rapidly by somatosensory input. |
Databáze: | OpenAIRE |
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