A bronze-tomato enriched diet affects the intestinal microbiome under homeostatic and inflammatory conditions
| Autor: | Marina Liso, Angelo Santino, Manuela Dicarlo, Eugenio Butelli, Anastasia Sobolewski, Aurelia Scarano, Cathie Martin, Stefania De Santis, Vanessa Galleggiante, Mirco Vacca, Pietro Campiglia, Grazia Serino, Antonio Lippolis, Maria De Angelis, Marcello Chieppa, Giulio Verna, Mauro Mastronardi |
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| Přispěvatelé: | Liso, M., De Santis, S., Scarano, A., Verna, G., Dicarlo, M., Galleggiante, V., Campiglia, P., Mastronardi, M., Lippolis, A., Vacca, M., Sobolewski, A., Serino, G., Butelli, E., De Angelis, M., Martin, C., Santino, A., Chieppa, M. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine Anti-Inflammatory Agents Bronze tomatoe murine models Gut flora Mice 0302 clinical medicine Solanum lycopersicum Intestinal inflammation RNA Ribosomal 16S Nutrition and Dietetics Microbiota Interleukin-17 Ulcerative colitis inflammatory bowel disease (IBD) Intestinal Microbiome Inflammatory bowel disease (IBD) 030211 gastroenterology & hepatology lcsh:Nutrition. Foods and food supply lcsh:TX341-641 Biology Article bronze tomatoes Interferon-gamma 03 medical and health sciences Immune system medicine microbiota Animals polyphenols Inflammation Bacteria Polyphenols Inflammatory Bowel Diseases medicine.disease biology.organism_classification Diet Gastrointestinal Microbiome Mice Inbred C57BL Disease Models Animal 030104 developmental biology Fruit Immunology Dysbiosis Colitis Ulcerative IL17A Intestinal bacteria Murine model Homeostasis Food Science |
| Zdroj: | Nutrients 10 (2018). doi:10.3390/nu10121862 info:cnr-pdr/source/autori:Marina Liso, Stefania De Santis, Aurelia Scarano, Giulio Verna Manuela Dicarlo, Vanessa Galleggiante, Pietro Campiglia, Mauro Mastronardi, Antonio Lippolis, Mirco Vacca, Anastasia Sobolewski, Grazia Serino, Eugenio Butelli, Maria De Angelis, Cathie Martin, Angelo Santino, Marcello Chieppa/titolo:A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions/doi:10.3390%2Fnu10121862/rivista:Nutrients/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:10 Nutrients Volume 10 Issue 12 Nutrients, Vol 10, Iss 12, p 1862 (2018) |
| DOI: | 10.3390/nu10121862 |
| Popis: | Inflammatory bowel diseases (IBD) are debilitating chronic inflammatory disorders that develop as a result of a defective immune response toward intestinal bacteria. Intestinal dysbiosis is associated with the onset of IBD and has been reported to persist even in patients in deep remission. We investigated the possibility of a dietary-induced switch to the gut microbiota composition using Winnie mice as a model of spontaneous ulcerative colitis and chow enriched with 1% Bronze tomato. We used the near isogenic tomato line strategy to investigate the effects of a diet enriched in polyphenols administered to mild but established chronic intestinal inflammation. The Bronze-enriched chow administered for two weeks was not able to produce any macroscopic effect on the IBD symptoms, although, at molecular level there was a significant induction of anti-inflammatory genes and intracellular staining of T cells revealed a mild decrease in IL17A and IFN&gamma production. Analysis of the microbial composition revealed that two weeks of Bronze enriched diet was sufficient to perturb the microbial composition of Winnie and control mice, suggesting that polyphenol-enriched diets may create unfavorable conditions for distinct bacterial species. In conclusion, dietary regimes enriched in polyphenols may efficiently support IBD remission affecting the intestinal dysbiosis. |
| Databáze: | OpenAIRE |
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