Red cell acid phosphatase: Another polymorphism correlated with malaria?
| Autor: | R. Palmarino, R. Agostino, L. Businco, G. Antognoni, E. Bottini, F. Gloria, Paola Lucarelli, P. L. Workman, G. Maggioni |
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| Rok vydání: | 1975 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Erythrocytes Thalassemia Acid Phosphatase Malaria morbidity Gene Frequency Polymorphism (computer science) hemic and lymphatic diseases Internal medicine parasitic diseases medicine Animals Allele Alleles Genetics Polymorphism Genetic biology Red cell acid phosphatase Altitude Acid phosphatase Favism medicine.disease Phenotype Malaria Glucosephosphate Dehydrogenase Deficiency Endocrinology Italy Anthropology biology.protein Female Anatomy |
| Zdroj: | American Journal of Physical Anthropology. 43:177-185 |
| ISSN: | 1096-8644 0002-9483 |
| DOI: | 10.1002/ajpa.1330430205 |
| Popis: | The frequency of PC allele for acid phosphatase in fourteen Sardinian villages correlates positively with the altitude and negatively with past malarial morbidity and GdMed prevalence. The susceptibility towards hemolytic favism in Sardinian males with G6PD deficiency is dependent on the erythrocyte acid phosphatase and thalassemia phenotypes. Thalassemia trait exerts a protective action only in subjects carrying PA allele for acid phosphatase. The data suggest that the gradient for malaria morbidity directly or indirectly, through interactions with thalassemia and G6PD polymorphisms, mediated by the habit of eating Vecia faba, may have had a significant role in determining the heterogeneous distribution of acid phosphatase polymorphism in Sardinia. Besides malaria, other environmental factors related with altitude seem to have been very important in shaping the present pattern of distribution of both acid phosphatase and G6PD polymorphisms in Sardinia. |
| Databáze: | OpenAIRE |
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