Opioid and cocaine combined effect on cocaine-induced changes in HPA and HPG axes hormones in men
| Autor: | Nancy K. Mello, Nathalie V. Goletiani, Michelle B. Sholar, Jack H. Mendelson, Arthur J. Siegel |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Hydrocortisone medicine.drug_class Narcotic Antagonists Clinical Biochemistry Analgesic Nalbuphine Adrenocorticotropic hormone Pharmacology Toxicology Biochemistry Article Young Adult Behavioral Neuroscience Adrenocorticotropic Hormone Cocaine Double-Blind Method Internal medicine medicine Humans Drug Interactions Testosterone Gonadal Steroid Hormones Gonads Opioid peptide Biological Psychiatry Dose-Response Relationship Drug business.industry Luteinizing Hormone Hormones Analgesics Opioid Endocrinology Opioid Corticosteroid business Glucocorticoid medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 91:526-536 |
| ISSN: | 0091-3057 |
| Popis: | Nalbuphine, a mixed micro-/kappa-opioid analgesic, may have potential as a new medication for the treatment of cocaine abuse. Kappa-opioid agonists functionally antagonize some abuse-related and locomotor effects of cocaine, and both kappa-selective and mixed micro-/kappa-opioids reduce cocaine self-administration by rhesus monkeys. Because cocaine's interactions with the hypothalamic-pituitary-adrenal and (HPA) hypothalamic-pituitary-gonadal (HPG) axes may contribute to its reinforcing properties, we examined the effects of cocaine alone and in combination with nalbuphine. Neuroendocrine effects of a single dose of cocaine alone (0.2 mg/kg, IV), with nalbuphine (5 mg/70 kg, IV)+cocaine (0.2 mg/kg, IV) in combination were compared in seven adult men (ages 18-35) who met DSM-IV criteria for current cocaine abuse. Cocaine alone, and in combination with nalbuphine was administered on separate test days under placebo-controlled, double blind conditions. Cocaine stimulated ACTH, cortisol, and LH, whereas cocaine+nalbuphine in combination produced a smaller increase in ACTH, and decreased cortisol and LH. Thus it appears that nalbuphine attenuated cocaine's effects on ACTH, cortisol, and LH. These data are consistent with our earlier report that nalbuphine modestly attenuated cocaine's positive subjective effects, and that the subjective and cardiovascular effects of cocaine+nalbuphine in combination were not additive. |
| Databáze: | OpenAIRE |
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