Role of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the treatment of patients with HIV infection
| Autor: | Lyn R. Frumkin |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Neutropenia
AIDS-Related Opportunistic Infections Neutrophils business.industry Human immunodeficiency virus (HIV) Granulocyte-Macrophage Colony-Stimulating Factor HIV Infections Hematology Granulocyte medicine.disease_cause medicine.disease Recombinant Proteins Granulocyte colony-stimulating factor Haematopoiesis medicine.anatomical_structure Granulocyte macrophage colony-stimulating factor Granulocyte macrophage colony-stimulating factor receptor Granulocyte Colony-Stimulating Factor Adjunctive treatment Immunology medicine Humans business medicine.drug |
| Zdroj: | Current Opinion in Hematology. 4:200-206 |
| ISSN: | 1065-6251 |
| DOI: | 10.1097/00062752-199704030-00008 |
| Popis: | The recombinant human colony-stimulating factors, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are hematopoietic cytokines that increase neutrophil number and enhance their function. In patients with HIV infection, G-CSF and GM-CSF have reversed or prevented neutropenia even during periods of full-dose myelotoxic therapy. Both colony-stimulating factors (CSFs) also have improved defects in neutrophil function in the setting of HIV infection. In non-neutropenic animal models of opportunistic bacterial or fungal infections, use of CSFs has increased survival. Future clinical applications of CSFs may include the adjunctive treatment of specific HIV-related opportunistic infections in addition to an expanding role in the treatment of HIV-associated neutropenia and defects in neutrophil function. |
| Databáze: | OpenAIRE |
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