Evaluation of dynamic headspace with gas chromatography/mass spectrometry for the determination of 1,1,1-trichloroethane, trichloroethanol, and trichloroacetic acid in biological samples
| Autor: | Russell L. Dills, Douglas O. Johns, Michael S. Morgan |
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| Rok vydání: | 2005 |
| Předmět: |
Analyte
Chromatography Clinical Biochemistry Ethylene Chlorohydrin Cell Biology General Medicine Urine Mass spectrometry Biochemistry Gas Chromatography-Mass Spectrometry Analytical Chemistry chemistry.chemical_compound chemistry 1 1 1-Trichloroethane Humans Trichloroethanes Gas chromatography Trichloroacetic Acid Gas chromatography–mass spectrometry Trichloroacetic acid Quantitative analysis (chemistry) |
| Zdroj: | Journal of Chromatography B. 817:255-261 |
| ISSN: | 1570-0232 |
| DOI: | 10.1016/j.jchromb.2004.12.013 |
| Popis: | A sensitive and reproducible method is described for the analysis of trichloroacetic acid in urine and 1,1,1-trichloroethane in blood using dynamic headspace GC/MS. Samples were analyzed using the soil module of a modified purge and trap autosampler to facilitate the use of disposable purging vessels. Coefficients of variation were below 3.5% for both analytes, and response was linear in the range of 0.01-7.0 microg/ml for trichloroacetic acid and 0.9 ng/ml-2.2 microg/ml for 1,1,1-trichloroethane. Attempts at using dynamic headspace for the analysis of trichloroethanol in urine were unsuccessful. |
| Databáze: | OpenAIRE |
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