Chromosomal imbalances in primary hepatic carcinosarcoma
| Autor: | Stefan Schweyer, Inga-Marie Schaefer, Jens Kuhlgatz |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Biology medicine.disease_cause Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Carcinosarcoma Serum response factor medicine Humans Aged Chromosome Aberrations Comparative Genomic Hybridization Liver Neoplasms medicine.disease 3. Good health Tumor progression 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Immunohistochemistry 030211 gastroenterology & hepatology Carcinogenesis Immunostaining Comparative genomic hybridization |
| Zdroj: | Human Pathology. 43:1328-1333 |
| ISSN: | 0046-8177 |
| DOI: | 10.1016/j.humpath.2011.11.007 |
| Popis: | Hepatic carcinosarcoma is an infrequent biphasic tumor composed of carcinomatous and sarcomatous elements, harboring an unfavorable prognosis. The developmental origin of both tumor components and possible molecular genetic mechanisms involved in tumorigenesis are still unclear. We report here a case of hepatic carcinosarcoma in a 76-year-old patient. The tumor was surgically resected and examined histopathologically including immunohistochemical staining. Focal hepatocellular differentiation was detected in the carcinomatous components but also in the pleomorphic undifferentiated spindle cells. Comparative genomic hybridization revealed amp 1q, -4q, -5p14pter, -5q13q31, +6p, -6q, -8p12pter, -12p, -13q12q14, -14q in the carcinomatous components, and +6p, -10q25qter, -22q in the sarcomatous components. The common +6p harbors the serum response factor gene encoding a transcription factor involved in cell proliferation, migration, and differentiation, confirmed by immunostaining. Hepatic carcinosarcoma is a tumor with biphasic morphology but possible monoclonal origin, showing advanced tumor progression in the carcinomatous areas. |
| Databáze: | OpenAIRE |
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