Undifferentiated spondyloarthritis: a longterm followup
| Autor: | Adil Muhib Samara, Manoel Barros Bertolo, Lilian Tereza Lavras Costallat, Roseneide A. Conde, Adriana Bruscato Bortoluzzo, Percival D. Sampaio-Barros |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology Black People White People Cohort Studies Psoriatic arthritis Rheumatology Asian People Japan Internal medicine Terminology as Topic Spondylarthritis Immunology and Allergy Medicine Humans Genetic Predisposition to Disease Spondylitis Ankylosing Prospective Studies Prospective cohort study HLA-B27 Antigen HLA-B27 Ankylosing spondylitis business.industry Sacroiliitis Buttock Pain Sacroiliac Joint medicine.disease Low back pain Surgery Disease Progression Female medicine.symptom business Brazil Follow-Up Studies |
| Zdroj: | The Journal of rheumatology. 37(6) |
| ISSN: | 0315-162X |
| Popis: | Objective.To analyze the longterm followup of a series of Brazilian patients with undifferentiated spondyloarthritis (uSpA).Methods.Prospective study analyzing a group of 111 patients with the diagnosis of uSpA, fulfilling the European Spondylarthropathy Study Group and the Amor criteria, who were followed for 5 to 10 years in a single university referral center. Patients had their outcome analyzed at 5, 7, and 10 years.Results.There was a predominance of men (81.1%), white ethnicity (78.4%), and positive HLA-B27 (61.3%), with a mean age at onset of 27.2 years. Twenty-seven patients presented development to ankylosing spondylitis (AS; 24.3%) and 3 to psoriatic arthritis (PsA; 2.7%), while 25 patients (22.5%) went into remission during the followup. Univariate logistic regression analysis revealed that ethnicity, HLA-B27, buttock pain, inflammatory low back pain, ankle involvement, grade I sacroiliitis at the beginning of the study, and the use of sulfasalazine were statistically associated with progression to AS. Multivariate logistic regression analysis revealed that HLA-B27 (p = 0.035, OR 6.720, 95% CI 11.45–39.43) and buttock pain (p = 0.009, OR 6.211, 95% CI 1.591–24.25) were statistically associated with progression to AS.Conclusion.In a longterm followup of 111 Brazilian patients with uSpA, HLA-B27 and buttock pain were significant predictors of progression to a definite disease. |
| Databáze: | OpenAIRE |
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