Lymphatic Vessel Invasion As a Prognostic Factor in Patients With Primary Resected Adenocarcinomas of the Esophagogastric Junction
| Autor: | Burkhard H. A. von Rahden, Hubert J. Stein, J. Rüdiger Siewert, Marcus Feith, Karen Becker |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Cancer Research Prognostic factor medicine.medical_specialty Pathology Adolescent Esophageal Neoplasms Adenocarcinoma Gastroenterology Stomach Neoplasms Internal medicine medicine Lymphatic vessel Humans Neoplasm Invasiveness In patient Prospective Studies Esophagogastric junction Prospective cohort study Aged Lymphatic Vessels Aged 80 and over Univariate analysis business.industry Middle Aged Prognosis medicine.disease medicine.anatomical_structure Lymphatic system Oncology Multivariate Analysis Female Esophagogastric Junction business |
| Zdroj: | Journal of Clinical Oncology. 23:874-879 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2005.12.151 |
| Popis: | Purpose To evaluate the value of lymphatic vessel invasion (LVI) as a predictor of survival in patients with primary resected adenocarcinomas of the esophagogastric junction (AEG). Patients and Methods We prospectively evaluated 459 patients undergoing primary surgical resection for tumors of the esophagogastric junction at our institution between 1992 and 2000 (180 adenocarcinomas of the distal esophagus, AEG I; 140 carcinomas of the cardia, AEG II; and 139 subcardial gastric cancers, AEG III). Median follow-up was 36.8 months. The prevalence of LVI was evaluated by two independent pathologists. Univariate and multivariate analysis of prognostic factors was performed. Results The total rate of LVI was 49.9%, with a significant difference between AEG I (38.9%) and AEGII/III (57.0%, P = .0002). Univariate analysis showed a significant correlation between LVI and T category (P < .0001), N category (P < .0001), and resection status (R [residual tumor] category; P < .0001). This was shown for the group of all AEG tumors, as well as for the subgroups AEG I and AEG II/III. On multivariate analysis, LVI was identified as a significant and independent prognostic factor (P = .050) in the population of all patients and in patients with AEG II/III, but not in the subgroup with AEG I. Conclusion These data demonstrate the prognostic significance of LVI in patients with AEG tumors, with marked differences between the subgroups AEG I versus AEG II/III. The lower prevalence and lack of prognostic significance of LVI in AEG I might be explained by inflammation involved in the pathogenesis of this entity. |
| Databáze: | OpenAIRE |
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