Metastasis in context: Modeling the tumor microenvironment with cancer-on-a-chip approaches
| Autor: | Sleeboom, Jelle F., Amirabadi, Hossein Eslami, Nair, Poornima, Sahlgren, Cecilia M., Den Toonder, Jaap M.J., Afd Pharmacology, Pharmacology |
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| Přispěvatelé: | Afd Pharmacology, Pharmacology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Population Microfluidics Neuroscience (miscellaneous) lcsh:Medicine Medicine (miscellaneous) Review Biology Cancer-on-a-chip Biochemistry Models Biological General Biochemistry Genetics and Molecular Biology Metastasis Extracellular matrix 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Immunology and Microbiology (miscellaneous) Models Neoplasms lcsh:Pathology medicine Animals Humans Tissue mechanics Microfluidics/methods Neoplasm Metastasis education Cancer Tumor microenvironment education.field_of_study Biochemistry Genetics and Molecular Biology(all) lcsh:R Extracellular Matrix/metabolism Biological medicine.disease Primary tumor Extracellular Matrix 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Local environment Neoplasms/metabolism lcsh:RB1-214 Genetics and Molecular Biology(all) |
| Zdroj: | DMM Disease Models and Mechanisms, 11(3). Company of Biologists Ltd Disease Models & Mechanisms Disease Models & Mechanisms, Vol 11, Iss 3 (2018) |
| ISSN: | 1754-8403 |
| Popis: | Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process. Cues from the tumor microenvironment, such as the biochemical composition, cellular population, extracellular matrix, and tissue (fluid) mechanics, have been indicated to play a pivotal role in the onset of metastasis. Dissecting the role of these cues from the tumor microenvironment in a controlled manner is challenging, but essential to understanding metastasis. Recently, cancer-on-a-chip models have emerged as a tool to study the tumor microenvironment and its role in metastasis. These models are based on microfluidic chips and contain small chambers for cell culture, enabling control over local gradients, fluid flow, tissue mechanics, and composition of the local environment. Here, we review the recent contributions of cancer-on-a-chip models to our understanding of the role of the tumor microenvironment in the onset of metastasis, and provide an outlook for future applications of this emerging technology. Summary: This Review evaluates the recent contributions of cancer-on-a-chip models to our understanding of the tumor microenvironment and its role in the onset of metastasis. The authors also provide an outlook for future applications of this emerging technology. |
| Databáze: | OpenAIRE |
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