Glycosaminoglycans from Alzheimer’s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau
| Autor: | Rita Raisman-Vozari, Joao Vilares, Gilles Carpentier, Mohand Ouidir Ouidja, Dulce Papy-Garcia, Auriane Maïza, Sandrine Chantepie, Ganlin Zhang, Minh Bao Huynh |
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| Přispěvatelé: | Croissance cellulaire, réparation et régénération tissulaires (CRRET), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Federal University of Sao Paulo (Unifesp), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Vascular Endothelial Growth Factor A Physiology [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Plasma protein binding Hippocampus Extracellular matrix Glycosaminoglycan chemistry.chemical_compound Binding Analysis 0302 clinical medicine Sulfation Endocrinology Medicine and Health Sciences Homeostasis Enzyme-linked immunoassays Tissue homeostasis Glycosaminoglycans Aged 80 and over Multidisciplinary Chemistry Chondroitin Sulfates Chemical Reactions Brain Drugs Neurodegenerative Diseases Heparin Middle Aged Alzheimer's disease Temporal Lobe Cell biology Extracellular Matrix Neurology Physical Sciences Medicine Female Fibroblast Growth Factor 2 Anatomy Growth factors Brazil medicine.drug Research Article Protein Binding Science tau Proteins Research and Analysis Methods DNA-binding protein 03 medical and health sciences Cell binding assay Alzheimer Disease Mental Health and Psychiatry medicine Chondroitin Humans Immunoassays Chemical Characterization Aged Pharmacology Endocrine Physiology Brain-Derived Neurotrophic Factor Biology and Life Sciences 030104 developmental biology Immunologic Techniques Dementia Heparitin Sulfate Physiological Processes 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2019, 14 (1), pp.e0209573. ⟨10.1371/journal.pone.0209573⟩ PLOS ONE PLoS ONE, Vol 14, Iss 1, p e0209573 (2019) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0209573⟩ |
| Popis: | International audience; Glycosaminoglycans (GAGs), including heparan sulfates and chondroitin sulfates, are major components of the extracellular matrix. Upon interacting with heparin binding growth factors (HBGF), GAGs participate to the maintaintenance of tissue homeostasis and contribute to self-healing. Although several processes regulated by HBGF are altered in Alzheimer’s disease, it is unknown whether the brain GAG capacities to bind and regulate the function of HBGF or of other heparin binding proteins, as tau, are modified in this disease. Here, we show that total sulfated GAGs from hippocampus of Alzheimer’s disease have altered capacities to bind and potentiate the activities of growth factors including FGF-2, VEGF, and BDNF while their capacity to bind to tau is remarkable increased. Alterations of GAG structures and capacities to interact with and regulate the activity of heparin binding proteins might contribute to impaired tissue homeostasis in the Alzheimer’s disease brain. |
| Databáze: | OpenAIRE |
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