Neutrophil Function in Dogs with Congenital Ciliary Dyskinesia
| Autor: | M. A. Barnhill, J. M. Maddux, W. L. Sanders, David F. Edwards |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
English Springer spaniel medicine.medical_specialty Pathology Free Radicals Neutrophils 040301 veterinary sciences biology.animal_breed Ciliary dyskinesia Immunoglobulins Breeding Granulocyte Immunoglobulin E 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine Phagocytosis In vivo Internal medicine Cell Adhesion medicine Animals Ingestion Dog Diseases 030223 otorhinolaryngology Respiratory Burst General Veterinary biology Nitroblue Tetrazolium Cilium Antibody-Dependent Cell Cytotoxicity 04 agricultural and veterinary sciences Oxygen Chemotaxis Leukocyte Endocrinology medicine.anatomical_structure biology.protein Ciliary Motility Disorders Female Oxidation-Reduction Iodine |
| Zdroj: | Veterinary Pathology. 28:347-353 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/030098589102800501 |
| Popis: | In vitro neutrophil function was assessed in two English Springer Spaniel dogs, two Bichon Frise dogs, and one Chow Chow dog with congenital ciliary dyskinesia; three clinically normal English Springer Spaniel dogs that were presumed heterozygous for congenital ciliary dyskinesia; and five control dogs. Chemotaxis and random migration in affected and heterozygous dogs were found to be comparable to those of control dogs. Increased (P less than or equal to 0.05) neutrophil adhesion, antibody dependent cell-mediated cytotoxicity, iodination of proteins, and oxygen radical production in neutrophils from affected dogs were probably the result of chronic bacterial infection in vivo. Bacterial ingestion by neutrophils from the three heterozygous English Springer Spaniel dogs was significantly increased compared to control dogs but was not different from affected English Springer Spaniel dogs, suggesting a breed-related phenomenon. Significant decreases in neutrophil function were not seen in any of the dogs with congenital ciliary dyskinesia, indicating that a defective microtubular system is not shared by respiratory cilia and neutrophils and that defective neutrophil function does not contribute to respiratory infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|