Diagnostic performance of basal free cortisol/18-hydroxy-11-deoxycorticosterone (18-OH-DOC) ratio in endogenous depression: Comparison with the dexamethasone suppression test
| Autor: | José Sulon, Remy von Frenckell, Jean-Jacques Legros, Marc Ansseau, Vincent Geenen, Patrick Papart, Georges Franck, Jean-Luc Cerfontaine, Demey-Ponsart E |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone medicine.medical_treatment Endogeny Dexamethasone Basal (phylogenetics) chemistry.chemical_compound Internal medicine medicine Humans Desoxycorticosterone Biological Psychiatry Depression (differential diagnoses) Aged Depressive Disorder business.industry Middle Aged Steroid hormone Endocrinology chemistry Dexamethasone suppression test Endogenous depression Female 11-Deoxycorticosterone business 18-Hydroxydesoxycorticosterone medicine.drug |
| Zdroj: | Biological Psychiatry. 22:947-956 |
| ISSN: | 0006-3223 |
| Popis: | We assessed the 8:00 am ratio of free cortisoll 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) in 56 endogenous depressive inpatients and in 22 normal volunteers. A ratio higher than 40 was associated with a diagnostic sensitivity for endogenous depression of 75%, a specificity of 95.5%, and a diagnostic confidence of 97.7%. These diagnostic results were at least equivalent to the Dexamethasone Suppression Test (DST) using a cortisol cut-off limit of 5 μg/dl. This may thus represent a simpler procedure than the DST in the diagnostic analysis of endogenous depression. |
| Databáze: | OpenAIRE |
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