Invasive micropapillary carcinoma of the breast has a better long-term survival than invasive ductal carcinoma of the breast in spite of its aggressive clinical presentations: a comparison based on large population database and case-control analysis
| Autor: | Maoli Wang, Kejin Wu, Hongliang Chen, Peng Zhang, Fuwen Wang, Mingdi Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research Time Factors Multivariate analysis Databases Factual Kaplan-Meier Estimate computer.software_genre 0302 clinical medicine Risk Factors Epidemiology skin and connective tissue diseases Original Research Database Carcinoma Ductal Breast Middle Aged case–control analysis Treatment Outcome Breast cancer‐specific survival Receptors Estrogen Lymphatic Metastasis 030220 oncology & carcinogenesis Disease Progression Female Receptors Progesterone medicine.medical_specialty overall survival Breast Neoplasms Subgroup analysis Disease-Free Survival 03 medical and health sciences Internal medicine Progesterone receptor Biomarkers Tumor invasive ductal carcinoma medicine Humans Neoplasm Invasiveness Radiology Nuclear Medicine and imaging Propensity Score Neoplasm Staging Proportional Hazards Models Retrospective Studies Chi-Square Distribution Proportional hazards model business.industry Clinical Cancer Research Retrospective cohort study Carcinoma Papillary United States 030104 developmental biology Multivariate Analysis Propensity score matching Neoplasm Grading invasive micropapillary carcinoma of the breast business computer Chi-squared distribution SEER Program |
| Zdroj: | Cancer Medicine |
| ISSN: | 2045-7634 |
| DOI: | 10.1002/cam4.1227 |
| Popis: | There are controversies in the comparison of overall survival between invasive micropapillary carcinoma of the breast (IMPC) and invasive ductal carcinoma (IDC). The objective of this study was to compare the long‐term survival outcome between non‐metastatic IMPC and IDC. The Surveillance, Epidemiology, and End Results database was searched to identify women with non‐metastatic IMPC and IDC diagnosed between 2001 and 2013. Comparisons of patient and tumor characteristics were performed using Pearson's chi‐square. The propensity score matching method was applied with each IMPC matched to one IDC. Breast cancer‐specific survival (BCSS) and overall survival (OS) were estimated using the Kaplan–Meier product limit method and compared across groups using the log‐rank statistic. Multivariate analysis was performed through Cox models. IMPC was presented with aggressive clinical presentations such as larger tumor, more positive lymph nodes, and more advanced stage compared with IDC. A higher rate of estrogen receptor (ER)/progesterone receptor (PR) positivity was also observed in IMPC. With a median follow‐up of 64 months, IMPC had a better BCSS (P = 0.031) and OS (P = 0.012) compared with IDC. In a case–control analysis IMPC was still an independent favorable prognostic factor for BCSS (HR = 0.410, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|