Effect of Gu Tong Xian capsule on expression level of type I, II collagen and BMP-2 mRNA in rabbits with fracture during long-distance running
| Autor: | Yueting Qiu, Liang Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology business.industry medicine.medical_treatment lcsh:RM1-950 Type II collagen Pharmaceutical Science Capsule Bone healing Anatomy Bone morphogenetic protein Bone morphogenetic protein 2 Andrology 03 medical and health sciences lcsh:Therapeutics. Pharmacology 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Medicine Original Article Sample collection business Saline Type I collagen |
| Zdroj: | Saudi Pharmaceutical Journal, Vol 25, Iss 4, Pp 513-516 (2017) |
| ISSN: | 1319-0164 |
| DOI: | 10.1016/j.jsps.2017.04.016 |
| Popis: | The study aims to analyze and investigate the effects of Gu Tong Xian Capsule on the expression level of type I, II collagen and BMP-2 mRNA in rabbits with fracture during long-distance running. 60 adult healthy rabbits were selected as research objects, and then randomly divided into three groups including model group, positive control group and treatment group, each containing 20 rabbits. The three groups were treated with saline gastric lavage, powder for fracture and trauma, and Gu Tong Xian capsule, respectively. The rabbits of the three groups were respectively sacrificed at 1st week, 2nd weeks and 4th week after operation for sample collection. After that, the expression levels of bone collagen type I, II and BMP-2 of three groups were measured and compared with each other. At all stages, the transcriptional level of type I collagen mRNA in the treatment group were significantly higher than that in the positive control group and model group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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