Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariea and schistosomes
| Autor: | A. Pieper, Dietrich W. Büttner, Norbert W. Brattig, M. Lintzel, F. W. Tischendorf |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Neutrophils
Veterinary (miscellaneous) Neurotoxins Eosinophil-derived neurotoxin Eosinophil-Derived Neurotoxin Biology Onchocerciasis Monocytes Dermatitis Atopic Elephantiasis Filarial Ribonucleases fluids and secretions Seroepidemiologic Studies Eosinophilia Eosinophil activation medicine Humans Schistosomiasis Peroxidase Eosinophil cationic protein Eosinophil Granule Proteins Blood Proteins Eosinophil medicine.disease Asthma Malaria Eosinophils Infectious Diseases medicine.anatomical_structure Insect Science Myeloperoxidase Africa Immunology biology.protein Sowda Parasitology medicine.symptom Biomarkers |
| Zdroj: | Acta Tropica. 62:171-182 |
| ISSN: | 0001-706X |
| DOI: | 10.1016/s0001-706x(96)00038-1 |
| Popis: | The serum levels of three major granulocyte proteins were measured in patients with onchocerciasis, bancroftian filariasis and intestinal schistosomiasis and compared to controls from patients with malaria, Africans living in areas not endemic for these infections and healthy Germans. The investigation comprised the determination of the eosinophil granule proteins eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN/EPX), and the neutrophil/monocyte granule protein myeloperoxidase (MPO). ECP and EDN/EPX levels were found elevated only in the three helminth infections that are associated with eosinophilia, while MPO was found elevated in all tested disease groups. The levels of eosinophil granule proteins observed in the helminth diseases by far exceeded those described for bronchial asthma and atopic dermatitis. ECP, EDN/EPX and MPO serum levels reflect the ongoing disease and are related to functional activity of the respective leukopoetic system. ECP and EDN/EPX appear to be markers of the eosinophil effector system and MPO a marker of the neutrophil and/or monocyte/macrophage effector system. Significantly higher ECP levels in chronic hyperreactive onchodermatitis (sowda) versus generalized onchocerciasis seem to reflect an augmented degree of antigenic stimulation, eosinophil activation and eosinophil turnover rates, indicating a more active mechanism of parasite clearance in sowda patients. |
| Databáze: | OpenAIRE |
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