Association between Polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and Colorectal Cancer Risk
| Autor: | Chiaki Nakarai, Shiro Kawamura, Minami Akiyama, Kenichi Tanaka, Yuko Takaoka, Akimitsu Tsutou, Kayo Osawa, Juro Takahashi, Masahiro Yamamoto, Ryuta Hashimoto, Etsuji Shimada, Masaya Kozuka, Yoshiaki Kido |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Oncology UGT1A6 Cancer Research medicine.medical_specialty Genotype Colon Epidemiology Colorectal cancer Adenocarcinoma medicine.disease_cause Bioinformatics Polymerase Chain Reaction UDP Glucuronosyltransferase Asian People Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Glucuronosyltransferase Carcinogen Aged Neoplasm Staging Polymorphism Genetic business.industry Smoking Rectum Public Health Environmental and Occupational Health Odds ratio Prognosis medicine.disease Confidence interval Case-Control Studies Tobacco exposure Female Colorectal Neoplasms Carcinogenesis business Polymorphism Restriction Fragment Length |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 13:2311-2314 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2012.13.5.2311 |
| Popis: | Genetic polymorphisms of uridine diphosphate-glucuronosyltransferases 1A6 (UGT1A6) and 1A7 (UGT1A7) may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interaction between polymorphisms of these repair genes and tobacco smoking in colorectal cancer (CRC). A total of 68 individuals with CRC and 112 non-cancer controls were divided into non-smoker and smoker groups according to pack-years of smoking. Genetic polymorphisms of UGT1A6 and UGT1A7 were examined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We found a weak association of UGT1A6 polymorphisms with CRC risk (crude odds ratio [OR], 1.65; 95% confidence interval [95%CI], 0.9-3.1, P=0.107; adjusted OR 1.95, 95%CI 1.0-3.8, P=0.051). The ORs for the UGT1A7 polymorphisms were statistically significant (crude OR: 26.40, 95%CI: 3.5-198.4, P=0.001; adjusted OR: 21.52, 95%CI: 2.8-164.1, P=0.003). The joint effect of tobacco exposure and UGT1A6 polymorphisms was significantly associated with colorectal cancer risk in non-smokers (crude OR, 2.11; 95%CI, 0.9-5.0, P=0.092; adjusted OR 2.63, 95%CI 1.0-6.7, P=0.042). In conclusion, our findings suggest that UGT1A6 and UGT1A7 gene polymorphisms are associated with CRC risk in the Japanese population. In particular, UGT1A6 polymorphisms may strongly increase CRC risk through the formation of carcinogens not associated with smoking. |
| Databáze: | OpenAIRE |
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