Efficacy and Safety of Fenfluramine in Autistic Children
| Autor: | John E. Overall, Phillip Adams, Elizabeth L. Curren, Richard Perry, Arthur M. Small, Lowell T. Anderson, Magda Campbell, Nona Lynch |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Clinical Trials as Topic Fenfluramine Symptom reduction medicine.disease Placebo Discrimination Learning Clinical trial Random Allocation Psychiatry and Mental health Rating scale Child Preschool Developmental and Educational Psychology medicine Humans Autism Female Discrimination learning Autistic Disorder Child Psychology Clinical psychology medicine.drug |
| Zdroj: | Journal of the American Academy of Child & Adolescent Psychiatry. 27:434-439 |
| ISSN: | 0890-8567 |
| Popis: | The short-term efficacy and safety of fenfluramine and its effects on discrimination learning in an automated laboratory were critically assessed in 28 autistic children. A parallel group design was employed: following a 2-week placebo baseline period, the children were randomly assigned to fenfluramine or placebo for a period of 8 weeks. Multiple, independent raters and multiple rating scales were used under three conditions. The results failed to show the superiority of fenfluramine over placebo in terms of symptom reduction. Furthermore, fenfluramine had a retarding effect on discrimination learning, employing the same tasks and methodology as in a previous controlled clinical trial. J. Am. Acad. Child Adolesc. Psychiatry , 1988, 27, 4:434–439. |
| Databáze: | OpenAIRE |
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