Impact of Age on Outcomes of Patients With Pure Carcinoma In Situ of the Bladder: Multi-Institutional Cohort Analysis
| Autor: | Matteo Ferro, Sever Chiujdea, Gennaro Musi, Giuseppe Lucarelli, Francesco Del Giudice, Rodolfo Hurle, Rocco Damiano, Francesco Cantiello, Andrea Mari, Andrea Minervini, Gian Maria Busetto, Giuseppe Carrieri, Felice Crocetto, Biagio Barone, Vincenzo Francesco Caputo, Luigi Cormio, Pasquale Ditonno, Alessandro Sciarra, Daniela Terracciano, Antonio Cioffi, Stefano Luzzago, Mattia Piccinelli, Francesco Alessandro Mistretta, Mihai Dorin Vartolomei, Ottavio de Cobelli |
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| Přispěvatelé: | Ferro, M., Chiujdea, S., Musi, G., Lucarelli, G., Giudice, F. D., Hurle, R., Damiano, R., Cantiello, F., Mari, A., Minervini, A., Busetto, G. M., Carrieri, G., Crocetto, F., Barone, B., Caputo, V. F., Cormio, L., Ditonno, P., Sciarra, A., Terracciano, D., Cioffi, A., Luzzago, S., Piccinelli, M., Mistretta, F. A., Vartolomei, M. D., de Cobelli, O. |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Carcinoma
Transitional Cell Aging Bladder cancer Oncological outcomes Progression Recurrence Urology Urinary Bladder Settore MED/24 - Urologia Cohort Studies carcinoma in situ aging oncological outcomes recurrence progression bladder cancer Oncology Urinary Bladder Neoplasms BCG Vaccine Disease Progression Humans Neoplasm Recurrence Local Carcinoma in Situ Aged Retrospective Studies Oncological outcome |
| Popis: | Introduction: The aim of this multicenter study was to investigate the role of age (cut-off 70 years) at diagnosis in predicting oncologic behavior of pure carcinoma in situ of the bladder. Material and Methods: Inclusion criteria were: patients with pure CIS confirmed and that followed intravesical BCG treatment. Pure CIS was defined at any CIS not associated with another urothelial cancer. Exclusion criteria were: any CIS associated with invasive urothelial carcinoma. A total of 172 with pure CIS treated between January 1, 2002 and December 31, 2012 at 8 academic institutions met the inclusion criteria. The maintenance schedule was generally according to the EAU guidelines at the time Results: A total of 99 (57.6%) patients had an age >70 years prior to TURBT. There was no difference between clinico-pathologic features among groups (group 1, age ≤ 70 years and group 2, age > 70 years), except that patients aged ≤ 70 years presented a larger size of CIS (35.6% vs. 21.2%), P =.02. In multivariable Cox regression analyses, the same clinico-pathologic factors (age, multifocality, and recurrent tumor state) were independently associated with worse RFS. Harrell's C-index was 65.75.In multivariable Cox regression analyses in addition to age (P =.006) and multifocality (P |
| Databáze: | OpenAIRE |
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